目的 探討注射用頭孢哌酮舒巴坦鈉聯(lián)合注射用替加環(huán)素治療多重耐藥肺炎克雷伯菌肺炎的應(yīng)用效果。方法 選取2020年1月—2022年12月銅陵市人民醫(yī)院收治的76例多重耐藥肺炎克雷伯菌肺炎患者作為研究對象，按隨機數(shù)字表法將所有患者分為對照組和治療組，各38例。對照組靜脈滴注注射用替加環(huán)素，50 mg/次，1次/12 h。治療組在對照組治療基礎(chǔ)上靜脈滴注注射用頭孢哌酮鈉舒巴坦鈉，2 g/次，生理鹽水100 mL稀釋，1次/6 h。兩組均連續(xù)治療7 d。比較兩組的臨床療效、細菌清除情況和血清炎癥指標(biāo)。結(jié)果 治療后，治療組的臨床治愈率為78.95%，明顯高于對照組的臨床治愈率55.26%（P＜0.05）。治療后，治療組的細菌清除率為81.58%，明顯高于對照組的細菌清除率55.26%（P＜0.05）。治療后，兩組血清指標(biāo)C-反應(yīng)蛋白（CRP）、白細胞介素-6（IL-6）和降鈣素原（PCT）水平均降低（P＜0.05），且治療組血清炎癥指標(biāo)低于對照組（P＜0.05）。結(jié)論 注射用頭孢哌酮舒巴坦鈉聯(lián)合注射用替加環(huán)素治療多重耐藥肺炎克雷伯菌肺炎的效果顯著，有效提高細菌清除率，減輕機體炎癥反應(yīng)。

Objective To investigate the effect of Cefoperazone Sodium and Sulbactam Sodium for injection combined with Tigecycline for injection in treatment of multidrug-resistant Klebsiella pneumoniae pneumonia. Methods Patients (76 cases) with multidrug-resistant Klebsiella pneumoniae pneumonia in Tongling People’s Hospital from January 2020 to December 2022 were divided into control and treatment groups according to random number table method, and each group had 38 cases. Patients in the control group were iv Tigecycline for injection, 50 mg/time, once every 12 h. Patients in the treatment group were iv Cefoperazone Sodium and Sulbactam Sodium for injection on the basis of the control group, 2 g/time, diluted with 100 mL normal saline, once every 6 h. Patients in two groups were treated for 7 d. The clinical efficacies, bacterial clearance, and serum inflammatory indexes in two groups were compared. Results After treatment, the clinical cure rate of the treatment group was 78.95%, which was significantly higher than that of the control group 55.26% (P < 0.05). After treatment, the bacterial clearance rate of the treatment group was 81.58%, which was significantly higher than 55.26% of the control group (P < 0.05). After treatment, the serum levels of CRP, IL-6, and PCT in two groups were decreased (P < 0.05), and the serum inflammation indexes in the treatment group were lower than those in the control group (P < 0.05). Conclusion Cefoperazone Sodium and Sulbactam Sodium for injection combined with Tigecycline for injection has a significant effect in treatment of multidrug-resistant Klebsiella pneumoniae pneumonia, which can effectively improve the bacterial clearance rate, reduce the inflammatory reaction of the body.

R974

安徽省危重癥呼吸疾病臨床醫(yī)學(xué)研究中心開放課題（LC202201）