目的 觀察蛭龍血通膠囊聯(lián)合長(zhǎng)春西汀注射液治療腦梗死恢復(fù)期的臨床效果。方法 選取2018年7月—2021年4月石河子大學(xué)第一附屬醫(yī)院收治的121例腦梗死恢復(fù)期患者，隨機(jī)數(shù)字表法將患者分為對(duì)照組（60例）和治療組（61例）。對(duì)照組患者靜脈滴注長(zhǎng)春西汀注射液，溶于250 mL生理鹽水中，初始劑量20 mg/次，視患者耐受情況逐漸加至30 mg/次，1次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服蛭龍血通膠囊，4粒/次，3次/d。兩組均連續(xù)治療2周。比較兩組的臨床療效、量表評(píng)分、血清神經(jīng)損傷指標(biāo)。結(jié)果 治療后，治療組的總有效率高于對(duì)照組（P＜0.05）。治療后，兩組美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分下降，日常生活能力量表（ADL）評(píng)分升高（P＜0.05），且治療組NIHSS評(píng)分顯著低于對(duì)照組，ADL評(píng)分高于對(duì)照組（P＜0.05）。治療后，兩組血清S100β蛋白、神經(jīng)元特異性烯醇化酶（NSE）、心型脂肪酸結(jié)合蛋白（H-FABP）水平均顯著下降（P＜0.05），且治療組血清神經(jīng)損傷指標(biāo)水平均顯著低于對(duì)照組（P＜0.05）。結(jié)論 蛭龍血通膠囊聯(lián)合長(zhǎng)春西汀注射液治療腦梗死恢復(fù)期療效較好，可促進(jìn)患者日常生活能力恢復(fù)、減輕神經(jīng)功能損傷。

Objective To observe the clinical effect of Zhilong Xuetong Capsules combine with Vinpocetine Injection in treatment of convalescent cerebral infarction. Methods Patients (121 cases) with convalescent cerebral infarction admitted to the First Affiliated Hospital of Shihezi University from July 2018 to April 2021 were randomly divided into control group (60 cases) and treatment group (61 cases) using a random number table method. Patients in the control group were iv administered with Vinpocetine Injection, the initial dose was 20 mg per time, dissolved in 250 mL physiological saline, gradually increasing to 30 mg/time depending on the patient's tolerance, once daily. Patients in the treatment group were orally administered Zhilong Xuetong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 weeks. The clinical efficacies, scale scores, and serum nerve injury indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group (P < 0.05). After treatment, NIHSS scores in two groups were decreased, while ADL scores in two groups were increased (P < 0.05). And NIHSS score in the treatment group was significantly lower than that in the control group, while ADL score in the treatment group was higher than that in the control group (P < 0.05). After treatment, the levels serum of S100β protein, NSE, and H-FABP in two groups were significantly decreased (P < 0.05), and the levels of serum nerve injury indicators in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Combination of Zhilong Xuetong Capsules and Vinpocetine Injection has clinical effect in treatment of convalescent cerebral infarction, can promote the recovery of patients’ daily living ability, and reduce their neurological damage.

R971

新疆生產(chǎn)兵團(tuán)指導(dǎo)性科技計(jì)劃項(xiàng)目（2022ZD072）