目的 探討愈風(fēng)寧心片聯(lián)合富馬酸比索洛爾片治療穩(wěn)定型心絞痛的臨床研究。方法 選取2020年10月—2022年10月戰(zhàn)略支援部隊特色醫(yī)學(xué)中心收治的110例穩(wěn)定型心絞痛患者，以不同治療方案分為對照組和治療組，各55例。對照組口服富馬酸比索洛爾片，起始劑量為2.5 mg/次，1次/d，根據(jù)患者情況調(diào)整劑量，每日不可超過10 mg。治療組在此基礎(chǔ)上口服愈風(fēng)寧心片，5片/次，3次/d。兩組治療1個月。觀察兩組的療效、心絞痛發(fā)作情況、血管內(nèi)皮功能因子。結(jié)果 治療組總有效率高于對照組（P＜0.05）。治療后，兩組患者心絞痛發(fā)作次數(shù)、平均持續(xù)時間均下降（P＜0.05），且治療組心絞痛發(fā)作次數(shù)、平均持續(xù)時間低于對照組（P＜0.05）。治療后，兩組血清內(nèi)皮素-1（ET-1）、血栓素B₂（TXB₂）水平均降低，一氧化氮（NO）水平均升高（P＜0.05），且治療組患者血清ET-1、TXB₂水平低于對照組，NO水平高于對照組（P＜0.05）。結(jié)論 愈風(fēng)寧心片聯(lián)合富馬酸比索洛爾片可提高穩(wěn)定型心絞痛的臨床療效，改善心絞痛發(fā)作情況和血管內(nèi)皮功能。

Objective To explore the clinical efficacy of Yufeng Ningxin Tablets combined with Bisoprolol Fumarate Tablets in treatment of stable angina pectoris. Methods A total of 110 patients with stable angina pectoris in Strategic Support Force Characteristic Medical Center from October 2020 to October 2022 were divided into control and treatment groups according to different treatment regimens, with 55 cases in each group. Patients in the control group were po administered with Bisoprolol Fumarate Tablets, with an initial dose of 2.5 mg, once daily. The dose was adjusted according to the patient's condition, and should not exceed 10 mg daily. On this basis, patients in the treatment group were po administered with Yufeng Ningxin Tablets, 5 tablets/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the curative effect, angina pectoris attack, and vascular endothelial function factor level of both groups were compared. Results Compared with the control group, the total effective rate of the treatment group was higher (P < 0.05). After treatment, the frequency and average duration of angina pectoris in two groups were decreased (P< 0.05), and the frequency and average duration of angina pectoris in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of endothelin 1 (ET-1) and thromboxane B₂ (TXB₂) decreased in both groups, while the levels of nitric oxide (NO) in two groups were increased (P < 0.05). Compared with control group, the serum levels of ET-1 and TXB₂ in the treatment group were lower, while the serum levels of NO in the treatment group were higher (P < 0.05). Conclusion Yufeng Ningxin Tablets combined with Bisoprolol Fumarate Tablets can improve the clinical efficacy of stable angina pectoris, improve the attack of angina pectoris and vascular endothelial function.

R972