目的 探討前列舒樂顆粒聯(lián)合非那雄胺片治療良性前列腺增生癥的臨床療效。方法 選取2021年1月—2022年12月如皋市人民醫(yī)院收治的100例良性前列腺增生癥患者，根據(jù)隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組各50例。對(duì)照組口服非那雄胺片，1片/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服前列舒樂顆粒，1袋/次，3次/d。兩組治療12周后統(tǒng)計(jì)療效。觀察兩組的臨床療效，比較兩組的臨床體征、臨床癥狀、尿動(dòng)力學(xué)、前列腺液炎癥因子水平。結(jié)果 治療后，治療組、對(duì)照組的總有效率為88.00%、72.00%，組間的差異顯著（P＜0.05）。治療后，兩組的前列腺體積（PV）、膀胱殘余尿量（RUV）低于治療前，最大尿流率（Q_max）高于治療前（P＜0.05）；治療組患者的PV、RUV低于對(duì)照組，Q_max高于對(duì)照組（P＜0.05）。治療后，兩組的國際前列腺癥狀評(píng)分（IPSS）評(píng)分顯著降低（P＜0.05），治療組較對(duì)照組IPSS評(píng)分降低更明顯（P＜0.05）。治療后，兩組的最大尿道閉合壓、最大尿道壓高低于治療前（P＜0.05），且治療組最大尿道閉合壓、最大尿道壓比對(duì)照組低（P＜0.05）。治療后，兩組前列腺液白細(xì)胞介素-8（IL-8）、前列腺特異性抗原（PSA）低于治療前（P＜0.05）；治療組的前列腺液IL-8、PSA低于對(duì)照組（P＜0.05）。結(jié)論 前列舒樂顆粒聯(lián)合非那雄胺片可提高良性前列腺增生癥的療效，顯著縮小前列腺體積和減輕臨床癥狀，改善尿動(dòng)力學(xué)水平，降低炎癥反應(yīng)。

Objective To investigate the clinical effect of Qianlie Shule Granules combined with Finasteride Tablets in treatment of benign prostatic hyperplasia. Methods Patients (100 cases) with benign prostatic hyperplasia in the People’s Hospital of Rugao from January 2021 to December 2022 were divided into control and treatment groups according to the random number table method, and each group had 50 cases. Patients in the control group were po administered with Finasteride Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Qianlie Shule Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and the clinical signs, symptoms, urodynamics, and levels of inflammatory factors in prostate fluid of two groups were compared. Results After treatment, the total effective rate of the treatment group was 88.00%, while the total effective rate of the control group was 72.00%, with significant differences between the groups (P< 0.05). After treatment, PV and RUV of two groups were lower than before treatment, while Q_max of two groups was higher than that of the control group (P < 0.05). PV and RUV of the treatment group were lower than those of the control group, while Q_max of the treatment group was higher than that of the control group (P < 0.05). After treatment, IPSS scores of two groups were significantly decreased (P < 0.05), and IPSS scores of the treatment group were more significant decrease than that of the control group (P< 0.05). After treatment, the maximum urethral closure pressure and maximum urethral pressure in two groups were lower than before treatment (P < 0.05), and the maximum urethral closure pressure and maximum urethral pressure in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of IL-8 and PSA in prostate fluid in two groups were lower than before treatment (P < 0.05). IL-8 and PSA levels in the prostate fluid of the treatment group were lower than those of the control group (P < 0.05). Conclusion Qianlie Shule Granules combined with Finasteride Tablets can improve the curative effect of benign prostatic hyperplasia, significantly reduce prostate volume and alleviate clinical symptoms, improve urodynamic levels, reduce inflammatory reactions.

R983

無錫市科技發(fā)展資金項(xiàng)目(N20192004)