目的 探討寬胸氣霧劑聯(lián)合非洛地平治療穩(wěn)定性心絞痛的臨床療效。方法 選取2020年11月-2022年11月文昌市人民醫(yī)院收治的118例穩(wěn)定性心絞痛患者，隨機(jī)法分為對(duì)照組（59例）和治療組（59例）。對(duì)照組口服非洛地平片，5 mg/次，1次/d。在對(duì)照組的基礎(chǔ)上，治療組口噴寬胸氣霧劑，舌下噴2撳/次，3次/d。兩組用藥28 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀改善時(shí)間，6 min步行距離，心絞痛發(fā)作次數(shù)和持續(xù)時(shí)間，血清因子血管內(nèi)皮素-1（ET-1）、同型半胱氨酸（Hcy）、基質(zhì)金屬蛋白酶-9（MMP-9）和白細(xì)胞介素-6（IL-6）水平。結(jié)果 治療后，治療組患者臨床有效率（98.31%）明顯高于對(duì)照組有效率（83.05%，P<0.05）。治療后，治療組臨床癥狀改善時(shí)間均早于對(duì)照組（P<0.05）。治療后，兩組的6 min步行距離明顯增加，而心絞痛發(fā)作次數(shù)和持續(xù)時(shí)間明顯下降（P<0.05），且治療組這些指標(biāo)均好于對(duì)照組（P<0.05）。治療后，兩組血清因子IL-6、Hcy、ET-1、MMP-9水平比治療前明顯下降（P<0.05），且治療組患者明顯低于對(duì)照組（P<0.05）。結(jié)論 寬胸氣霧劑聯(lián)合非洛地平治療穩(wěn)定性心絞痛效果確切，能明顯改善胸痛及胸悶等癥狀，并能有效促進(jìn)心絞痛發(fā)作次數(shù)及時(shí)間降低，促使炎性反應(yīng)減弱。

Objective To investigate the therapeutic effect of Kuanxiong Aerosol combined with felodipine in treatment of stable angina pectoris. Methods Patients (118 cases) with stable angina pectoris in Wenchang People's Hospital from November 2020 to November 2022 were randomly divided into control (59 cases) and treatment (59 cases) group. Patients in the control group were po administered with Felodipine Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Kuanxiong Aerosol on the basis of the control group sublingually, 2 press/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical evaluation was evaluated, and the relief time of symptom, 6 min walking distance, attacks and duration of angina pectoris, the levels of serum IL-6, Hcy, ET-1 and MMP-9 in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (98.31%) was significantly higher than that of the control group (83.05%, P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was earlier than that in the control group (P< 0.05). After treatment, the 6 min walking distance was significantly increased, while the frequency and duration of angina pectoris were significantly decreased in two groups (P < 0.05), and these indexes in the treatment group were better than those in the control group (P < 0.05). After treatment, the levels of serum factors IL-6, Hcy, ET-1 and MMP-9 in two groups were significantly lower than those before treatment (P< 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Felodipine combined with Kuanxiong Aerosol is effective in treatment of chest pain and chest tightness, and can effectively reduce the frequency and time of angina pectoris and weaken the inflammatory reaction.

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