乳腺癌是最常見的癌癥之一,屬于典型的異質(zhì)性惡性腫瘤,臨床結(jié)局不佳。雙氫青蒿素是青蒿素在體內(nèi)的主要代謝產(chǎn)物,可抑制乳腺癌腫瘤細(xì)胞增殖、促進(jìn)腫瘤細(xì)胞凋亡、阻止腫瘤細(xì)胞轉(zhuǎn)移、誘導(dǎo)細(xì)胞自噬,因此對(duì)雙氫青蒿素抗乳腺癌的作用機(jī)制進(jìn)行總結(jié),希望為雙氫青蒿素的臨床使用提供參考。

Breast cancer, one of the most common cancers, is a typical heterogeneous malignancy with poor clinical outcome.Dihydroartemisinin is the main metabolite of artemisinin in vivo. Dihydroartemisinin can inhibit the proliferation of breast cancer tumor cells, promote tumor cell apoptosis, prevent tumor cell metastasis, and induce autophagy. This article summarizes the mechanism of dihydroartemisinin against breast cancer, hoping to provide reference for the clinical use of dihydroartemisinin.

R979.1

河北省中醫(yī)藥管理局科研計(jì)劃項(xiàng)目(2019005)