目的 探討丹皮酚軟膏聯(lián)合他克莫司軟膏司治療皮膚瘙癢癥的臨床療效。方法 選取2020年2月—2023年1月在廊坊市人民醫(yī)院就診的92例皮膚瘙癢癥患者,根據(jù)計算機隨機排列法將92例患者分為對照組和治療組,每組各46例。對照組將他克莫司軟膏涂抹于患處,2次/d,2次間隔12 h;治療組患者在對照組治療的基礎(chǔ)上將丹皮酚軟膏涂抹于患處,1次/d。兩組患者連續(xù)治療4周。觀察兩組的臨床療效,比較兩組的瘙癢癥狀和血清因子水平。結(jié)果 治療后,治療組的總有效率93.48%明顯高于對照組的總有效率78.26%(P<0.05)。治療后,兩組的發(fā)作頻次、每次持續(xù)時間低于治療前(P<0.05);治療后,治療組發(fā)作頻次、每次持續(xù)時間均低于對照組(P<0.05)。治療后,兩組血清β-內(nèi)啡肽、5-羥色胺、白細胞介素-4(IL-4)水平低于治療前(P<0.05);治療后,治療組的血清β-內(nèi)啡肽、5-羥色胺、IL-4水平低于對照組(P<0.05)。結(jié)論 丹皮酚軟膏聯(lián)合他克莫司軟膏治療皮膚瘙癢癥的療效確切,能顯著減輕瘙癢癥狀,降低血清因子水平,且安全性較好。

Objective To investigate the clinical effect of Paeonol Ointment combined with Tacrolimus Ointment in treatment of skin pruritus.Methods Patients(92 cases) with skin pruritus in the People's Hospital of Langfang City from February 2020 to January 2023 were divided into control and treatment groups according to the computer random arrangement method, and each group had 46cases. Patients in the control group applied Tacrolimus Ointment to the affected area, twice daily, with an interval of 12 hours between two doses. Patients in the treatment group applied Paeonol Ointment to the affected area on the basis of the control group, once daily.Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and pruritus symptoms and factor levels in two groups were compared.Results After treatment, the total effective rate of 93.48% in the treatment group was significantly higher than 78.26% in the control group(P<0.05). After treatment, the frequency and duration of pruritus in two groups were decreased(P<0.05), and the frequency and duration of pruritus in the treatment group were lower than those in the control group(P<0.05). After treatment, the serum levels of β-endorphin, 5-hydroxytryptamine, and IL-4 in two groups were decreased(P<0.05),and the serum levels of β-endorphin, 5-hydroxytryptamine, and IL-4 in the treatment group were lower than those in the control group(P<0.05).Conclusion Paeonol Ointment combined with Tacrolimus Ointment is effective in treatment of skin pruritus, and can significantly reduce pruritus symptoms and serum factor levels, with good safety.

R986

廊坊市科技計劃項目(2016013012)