目的 探討烏雞白鳳丸聯(lián)合炔諾酮治療月經(jīng)不調(diào)的臨床療效。方法 選擇2021年10月—2022年10月河北以嶺醫(yī)院收治的100例月經(jīng)不調(diào)患者,采用隨機(jī)數(shù)字表法分對照組(50例)和治療組(50例)。對照組口服炔諾酮片,2.5 mg/次,2次/d。在對照組的基礎(chǔ)上,治療組口服烏雞白鳳丸,9 g/次,2次/d。兩組患者均治療14 d。觀察兩組患者臨床療效,比較治療前后兩組患者癥狀改善時間,性激素促卵泡成熟激素(FSH)、雌二醇(E₂)和黃體生成素(LH)水平,血清白細(xì)胞介素-6(IL-6)、血管內(nèi)皮生長因子(VEGF)、腫瘤壞死因子-α(TNF-α)和白細(xì)胞介素-1β(IL-1β)水平,及中華生存質(zhì)量(ChQOL)評分。結(jié)果 治療后,治療組患者總有效率(98.00%)明顯高于對照組(84.00%,P<0.05)。治療后,治療組癥狀改善時間均早于對照組(P<0.05)。治療后,兩組患者的FSH、LH水平明顯降低,而E₂水平明顯升高(P<0.05),且治療組性激素水平明顯好于對照組(P<0.05)。治療后,兩組血清炎性因子IL-6、TNF-α、IL-1β水平明顯低于治療前,而VEGF明顯高于治療前(P<0.05),且治療組血清炎性因子明顯好于對照組(P<0.05)。治療后,兩組患者ChQOL評分明顯升高(P<0.05),且治療組ChQOL評分明顯高于對照組(P<0.05)。結(jié)論 烏雞白鳳丸聯(lián)合炔諾酮治療療效確切,可有效改善癥狀,機(jī)體炎性反應(yīng)降低明顯,性激素水平改善明顯,提高患者生活質(zhì)量。

Objective To observe the therapeutic effect of Wuji Baifeng Pills combined with norethisterone in treatment of irregular menstruation.Methods Patients(100 cases) with irregular menstruation in Hebei Yiling Hospital from October 2021 to October 2022were divided into control group(50 cases) and treatment group(50 cases) by random number table method. Patients in the control group were po administered with Norethisterone Tablets, 2.5 mg/time, twice daily. Patients in the treatment group were po administered with Wuji Baifeng Pills on the basis of the control group, 9 g/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, and the symptom relief time, the levels of FSH, LH, E₂, IL-6, TNF-α, IL-1β and VEGF,quality of life score ChQOL in two groups before and after treatment were compared.Results After treatment, the clinical effective rate in the treatment group(98.00%) was significantly higher than that of the control group(84.00%, P<0.05). After treatment, the improvement time of symptom in the treatment group was earlier than that in the control group(P<0.05). After treatment, the levels of FSH and LH in two groups were significantly decreased, while the level of E₂ was significantly increased(P<0.05), and the level of sex hormone in the treatment group was significantly better than that in the control group(P<0.05). After treatment, the levels of serum inflammatory factors IL-6, TNF-α, and IL-1β in two groups were significantly lower than those before treatment(P<0.05),while the level of VEGF in the treatment group was significantly higher than that in the control group(P<0.05). After treatment, the ChQOL score in two groups was significantly increased, and the ChQOL score in the treatment group was significantly higher than that of the control group(P<0.05).Conclusion Wuji Baifeng Pills combined with norethisterone has a definite therapeutic effect,which can effectively improve the symptoms, reduce the organic inflammatory reaction, improve the level of sex hormone and improve the quality of life of the patients.

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