目的 探討腦立清丸聯(lián)合纈沙坦氨氯地平治療原發(fā)性高血壓的臨床療效。方法 選取2020年8月—2022年8月在河南中醫(yī)藥大學(xué)第三附屬醫(yī)院診治的116例高血壓患者,按照隨機(jī)數(shù)字表法將患者分為對照組(58例)和治療組(58例)。對照組患者口服纈沙坦氨氯地平片(Ⅰ),1片/次,1次/d。治療組在對照組的基礎(chǔ)上口服腦立清水丸,10丸/次,2次/d。兩組患者均治療14 d。觀察兩組患者臨床療效,比較治療前后兩組患者癥狀緩解時間,收縮壓(SBP)和舒張壓(DBP)水平,氧化應(yīng)激指標(biāo)丙二醛(MDA)、內(nèi)皮素-1(ET-1)、一氧化氮(NO)和超氧化物歧化酶(SOD)水平及不良反應(yīng)情況。結(jié)果 治療后,治療組總有效率(98.28%)顯著高于對照組(84.48%,P<0.05)。治療后,治療組患者頭暈、心悸、頭痛、氣短緩解時間均短于對照組(P<0.05)。治療后,兩組患者SBP、DBP水平比治療前明顯下降(P<0.05),且治療組患者血壓水平明顯優(yōu)于對照組(P<0.05)。治療后,兩組患者M(jìn)DA、ET-1明顯降低,而SOD和NO水平明顯升高(P<0.05),且治療組氧化應(yīng)激水平明顯好于對照組(P<0.05)。治療后,治療組不良反應(yīng)發(fā)生率(6.89%)明顯低于對照組(15.52%,P<0.05)。結(jié)論 腦立清丸聯(lián)合纈沙坦氨氯地平治療效果確切,可緩解癥狀,能有效減低患者高血壓,改善機(jī)體氧化應(yīng)激反應(yīng)狀態(tài)。

Objective To investigate the efficacy of Naoliqing Pills combined with valsartan amlodipine in treatment of primary hypertension.Methods Patients(116 cases) with primary hypertension in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from August 2020 to August 2022 were divided into control group(58 cases) and treatment group(58cases) according to random number table method. Patients in the control group were po administered with Valsartan and Amlodipine Tablets(Ⅰ), 1 tablet/time, once daily. Patients in the treatment group were po administered with Naoliqing Pills on the basis of the control group, 10 pills/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated,and the symptom relief time, the level of SBP and DBP, the levels of MDA, SOD, ET-1 and NO, and adverse reaction in two groups before and after treatment were compared.Results After treatment, the total effective rate of the treatment group(98.28%) was significantly higher than that of the control group(84.48%, P<0.05). After treatment, the relief time of dizziness, palpitation, headache and shortness of breath in the treatment group was shorter than that in the control group(P<0.05). After treatment, the levels of SBP and DBP in the two groups were significantly lower than those before treatment(P<0.05), and the blood pressure in the treatment group was significantly better than that in the control group(P<0.05). After treatment, the levels of MDA and ET-1 were significantly decreased, while the levels of SOD and NO were significantly increased in two groups(P<0.05), and the level of oxidative stress in the treatment group was significantly better than that in the control group(P<0.05). After treatment, the incidence of adverse reactions in the treatment group(6.89%) was significantly lower than that in the control group(15.52%, P<0.05).Conclusion Naoliqing Pills combined with valsartan amlodipine is effective in the treatment of symptoms, which can effectively reduce hypertension and improve the state of oxidative stress in patients.

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