糖尿病是全球最大的公共衛(wèi)生問題之一。二甲雙胍是糖尿病臨床治療的一線用藥，卻無法避免患者出現(xiàn)藥物不良反應(yīng)。二甲雙胍具有乳酸性酸中毒、胃腸道不良反應(yīng)、厭食、神經(jīng)系統(tǒng)的負面影響、維生素B12缺乏癥以及其他不良反應(yīng)。因此就二甲雙胍在糖尿病治療中的各種不良反應(yīng)及其分子機制進行綜述，以期為二甲雙胍的臨床使用提供一定的指導(dǎo)作用。

Diabetes is one of the biggest public health problems in the world. Metformin is the first-line drug for clinical treatment of diabetes, but it cannot avoid adverse drug reactions in patients. Metformin has various adverse reactions, such as lactic acid acidosis, gastrointestinal adverse reactions, anorexia, negative effects on the nervous system, vitamin B12 deficiency, and other adverse reactions. Therefore, this article reviews the adverse reactions of metformin in treatment of diabetes and their molecular mechanisms, with a view to guiding the clinical use of metformin.

R977

江蘇省第二批中醫(yī)藥領(lǐng)軍人才項目（SLJ0225）