目的 統(tǒng)計青島市精神衛(wèi)生中心2020—2022年抗精神病藥使用情況并分析變化趨勢，為臨床合理用藥提供參考。方法 采用回顧性分析方法統(tǒng)計青島市精神衛(wèi)生中心信息系統(tǒng)中2020年1月—2022年12月抗精神病藥的銷售金額，并計算用藥頻度（DDDs）、限定日費用（DDC）以及藥品排序比（B/A）。結(jié)果 2020—2022年，青島市精神衛(wèi)生中心抗精神病藥年銷售金額基本穩(wěn)定，奧氮平、喹硫平的銷售金額及排序始終居于前2位；抗精神病藥的DDDs呈現(xiàn)逐年增長的趨勢，奧氮平DDDs基本穩(wěn)定，始終居于第1位，喹硫平DDDs逐年增長，居于第2位；抗精神病藥的DDC及排序基本穩(wěn)定，帕利哌酮、氨磺必利、齊拉西酮、喹硫平的DDC排序始終居于前4位；阿立哌唑、氨磺必利、奧氮平、奮乃靜、氟哌啶醇、喹硫平、硫必利、氯丙嗪、齊拉西酮、五氟利多的B/A值接近于1.00。結(jié)論 青島市精神衛(wèi)生中心抗精神病藥的使用基本合理，后期仍需加強監(jiān)督管理，以保證患者合理用藥。

Objective To make statistics on the use of antipsychotics in Qingdao Mental Health Center from 2020 to 2022 and analyze the trend of change, so as to provide reference for clinical rational drug use. Methods The sales amount of antipsychotics from January 2020 to December 2022 in the information system of Qingdao Mental Health Center was analyzed retrospectively, and the DDDs, DDC, and B/A were calculated. Results From 2020 to 2022, the annual consumption sum of antipsychotics in Qingdao Mental Health Center was basically stable, and the consumption sum and order of olanzapine and quetiapine always ranked first and second. The DDDs of antipsychotics showed an increasing trend year by year, and the DDDs of olanzapineare were basically stable, always ranked first, while the DDDs of quetiapine were increasing year by year, ranking second. The DDC and order of antipsychotics were basically stable, among which the DDC and order of paliperidone, amisulpride, ziprasidone and quetiapine ranked the first 4. The B/A values of aripiprazole, amisulpride, olanzapine, perphenazine, haloperidol, quetiapine, thiopiride, chlorpromazine, ziprasidone and pentafluridol were close to 1.00. Conclusion The use of antipsychotics in Qingdao Mental Health Center was basically reasonable, and supervision and management should be strengthened in the later stage to ensure the rational drug use by patients.

R971