目的 探討香菊膠囊聯(lián)合鹽酸西替利嗪滴劑治療兒童過敏性鼻炎的臨床療效。方法 選取2020年9月—2022年3月在無錫市新吳區(qū)新瑞醫(yī)院就診的122例過敏性鼻炎患兒為研究對象，按照隨機數(shù)字表法將所有患兒分為對照組和治療組，每組各61例。對照組患兒口服鹽酸西替利嗪滴劑，1 mL/次，1次/d。治療組患兒在對照組治療的基礎上口服香菊膠囊，2～4粒/次，3次/d。兩組患兒連續(xù)服用4周。觀察兩組的臨床療效，比較兩組患兒血清免疫球蛋白、免疫功能、炎癥因子水平。結果 治療后，治療組的總有效率95.08%，明顯高于對照組的總有效率81.97%（P<0.05）。治療后，治療組患兒鼻塞、流涕、噴嚏、鼻癢緩解時間明顯短于對照組（P<0.05）。治療后，兩組血清免疫球蛋白E（IgE）、免疫球蛋白G（IgG）、白三烯B4（TB4）水平明顯低于治療前（P<0.05）；治療后，治療組血清IgE、IgG、LTB4水平低于對照組（P<0.05）。治療后，兩組血清CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺水平明顯高于治療前（P<0.05）；治療組血清CD3⁺、CD4⁺、CD4⁺/CD8⁺水平明顯高于對照組，血清CD8⁺水平低于對照組（P<0.05）。治療后，兩組血清白細胞介素-8（IL-8）、白細胞介素-4（IL-4）、白細胞介素-17（IL-17）水平均明顯低于治療前（P<0.05）；治療組血清IL-4、IL-8、IL-17水平均低于對照組（P<0.05）。結論 香菊膠囊聯(lián)合鹽酸西替利嗪滴劑治療兒童過敏性鼻炎具有較好的臨床療效，可有效提高患兒機體免疫能力，降低炎癥反應，且安全性較好。

Objective To investigate the clinical effect of Xiangju Capsules combined with Cetirizien Hydrochloride Drops in treatment of allergic rhinitis in children. Methods Children (122 cases) with allergic rhinitis in Wuxi Xinwu District Xinrui Hospital from September 2020 to March 2022 were divided into control and treatment groups according to the random number table method, and each group had 61 cases. Patients in the control group were po administered with Cetirizien Hydrochloride Drops, 1 mL/time, once daily. Patients in the treatment group were po administered with Xiangju Capsules on the basis of the control group, 2-4 capsules/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the serum immunoglobulin, immune function, and inflammatory factors levels in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.08%, significantly higher than the total effective rate of the control group of 81.97% (P < 0.05). After treatment, the remission time of nasal congestion, runny nose, sneezing, and itching in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the serum levels of IgE, IgG, and LTB4 in two groups were significantly lower than before treatment (P < 0.05). After treatment, the serum levels of IgE, IgG, and LTB4 in the treatment group were lower than those in the control group (P< 0.05). After treatment, the serum levels of CD3⁺, CD4⁺, CD8⁺, and CD4⁺/CD8⁺ in two groups were significantly higher than those before treatment (P < 0.05). The levels of serum CD3⁺, CD4⁺, CD4⁺/CD8⁺in the treatment group were significantly higher than those in the control group, while the levels of serum CD8⁺were lower than those in the control group (P < 0.05). After treatment, the levels serum of IL-4, IL-8, and IL-17 in both groups were significantly lower than those before treatment (P < 0.05). The serum levels of IL-4, IL-8, and IL-17 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Xiangju Capsules combined with Cetirizien Hydrochloride Drops is effective in treatment of allergic rhinitis in children, which can significantly reduce the inflammatory reaction of children, improve immune function, and have good safety.

R976