目的 探討除濕止癢軟膏聯(lián)合曲咪新乳膏治療兒童濕疹的臨床療效。方法 選取在2021年9月—2022年9月鄭州大學(xué)附屬兒童醫(yī)院收治的118例濕疹患兒，根據(jù)隨機(jī)數(shù)字表法將118例患兒分為對照組和治療組，每組各59例。對照組患兒每日晚上涂抹曲咪新乳膏1次。治療組在對照組基礎(chǔ)上每日早上外用均勻涂抹除濕止癢軟膏1次并輕揉。兩組患兒連續(xù)治療21 d。觀察兩組的臨床療效，比較兩組患兒的癥狀消失時間、皮損癥狀和血清指標(biāo)水平。結(jié)果 治療后，治療組的總有效率為94.92%，明顯高于對照組的總有效率83.05%，組間比較有顯著差異（P<0.05）。治療后，兩組的濕疹面積嚴(yán)重度指數(shù)（EASI）評分明顯降低（P<0.05），且治療組的EASI評分明顯低于對照組（P<0.05）。治療后，治療組瘙癢、疼痛、紅腫消失時間明顯短于對照組（P<0.05）。治療后，兩組的血清白細(xì)胞介素-4（IL-4）、白細(xì)胞介素-18（IL-18）、白細(xì)胞介素-23（IL-23）水平明顯降低（P<0.05），治療組的血清IL-4、IL-18、IL-23水平明顯低于對照組（P<0.05）。結(jié)論 除濕止癢軟膏聯(lián)合曲咪新乳膏有助于提高兒童濕疹的療效，顯著減輕臨床癥狀，降低炎癥反應(yīng)，安全性良好。

Objective To investigate the clinical effect of Chushi Zhiyang Ointments combined with Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Cream in treatment of children eczema. Methods Children (118 cases) with eczema in Children's Hospital Affiliated to Zhengzhou University from September 2021 to September 2022 were divided into control and treatment groups according to the random number table method, and each group had 59 cases. Patients in the control group were daubed with Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Creams, once every night. Patients in the treatment group were daubed with Chushi Zhiyang Ointments on the basis of the control group, once every morning and gently rubbed. Patients in two groups were treated for 21 d. After treatment, the clinical efficacies were evaluated, and the time of symptom disappearance, skin lesion symptoms, and serum indicator levels between two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.92%, which was significantly higher than that of the control group (83.05%), and there was a significant difference between the groups (P < 0.05). After treatment, the EASI score of two groups was significantly decreased (P< 0.05), and the EASI score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the disappearance times of pruritus, pain, and redness in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the serum levels of IL-4, IL-18, and IL-23 in two groups were significantly decreased (P < 0.05), and the serum levels of IL-4, IL-18, and IL-23 in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Chushi Zhiyang Ointments combined with Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Cream can improve the efficacy of children with eczema, significantly reduce clinical symptoms, reduce inflammatory response, with good safety.

R976

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目（LHGJ20210638）