目的 探究清咳平喘顆粒治療小兒支氣管哮喘急性期（熱哮證）的臨床療效。方法 選取2019年5月—2021年12月就診于山東中醫(yī)藥大學(xué)附屬醫(yī)院、山東中醫(yī)藥大學(xué)第二附屬醫(yī)院及濟(jì)南市中醫(yī)院兒科門診及住院60名支氣管哮喘患兒為研究對(duì)象，借助SAS 13.0軟件產(chǎn)生患者隨機(jī)表將患者分為對(duì)照組和治療組，每組各30例。對(duì)照組患者給予吸入用布地奈德混懸液1 mg/次，2次/d，硫酸特布他林霧化液2.5 mg/次，2次/d。治療組在對(duì)照組治療基礎(chǔ)上口服清咳平喘顆粒，3～6歲，1/2袋/次；7～12歲，1袋/次，3次/d。兩組療程均為5 d。觀察兩組的臨床療效，比較兩組治療前后中醫(yī)證候評(píng)分和肺功能指標(biāo)的變化情況。結(jié)果 治療后，治療組綜合療效總有效率為100%，顯著高于對(duì)照組的86.7%（P<0.05）。治療組中醫(yī)證候療效總有效率是100.0%，顯著高于對(duì)照組的86.7%（P<0.05）。治療后，兩組喘息評(píng)分、咳嗽咯痰評(píng)分、流涕評(píng)分、舌脈評(píng)分、中醫(yī)證候總積分均較治療前顯著降低（P<0.05）；且治療后，治療組中醫(yī)證候各評(píng)分及總分均顯著低于對(duì)照組（P<0.05）。治療后，兩組用力肺活量（FVC）、第1秒用力呼氣容積FEV1占預(yù)計(jì)值百分比（FEV1%）、呼氣峰流速PEFR占預(yù)計(jì)值的百分?jǐn)?shù)（PEFR%）均較同組治療前顯著提高（P<0.05）；且治療后，治療組FVC、FEV1%、PEFR%水平高于對(duì)照組（P<0.05）。結(jié)論 清咳平喘顆粒治療小兒支氣管哮喘急性期（熱喘證）具有較好的臨床療效，可顯著緩解患兒咳嗽、咯痰、喘息等癥狀，改善肺功能相關(guān)指標(biāo)。

Objective To study the clinical efficacy of Qingke Pingchuan Granules in treatment of acute stage of bronchial asthma in children (heat asthma syndrome). Methods Sixty children with bronchial asthma admitted to the Affiliated Hospital of Shandong University of Chinese Medicine, the Second Affiliated Hospital of Shandong University of Chinese Medicine and Jinan Hospital of Traditional Chinese Medicine from May 2019 to December 2021 were selected as the research objects. The patients were divided into control group and treatment group with 30 cases in each group by using SAS 13.0 software to generate patient randomization table. Patients in the control group were given Budesonide Suspension for inhalation 1 mg/time, twice daily, Terbutaline Sulphate Solution for nebulization 2.5 mg/time, twice daily. Patients in the treatment group were po administered with Qingke Pingchuan Granules on the basis of the control group, 3 to 6 years old, 1/2 bag/time; 7 to 12 years old, 1 bag/time, 3 times/day. The treatment course of bothgroups was 5 d. The clinical effects of the two groups were observed, and the changes of TCM syndrome scores and lung function indexes before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 100%, significantly higher than that of the control group (86.7%) (P < 0.05). The total effective rate of the treatment group was 100.0%, which was significantly higher than that of the control group (86.7%) (P < 0.05). After treatment, panting score, cough phlegm score, runny nose score, tongue and pulse score and total TCM syndrome score were significantly decreased in two groups compared with before treatment (P < 0.05). After treatment, TCM syndrome scores and total scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, forced vital capacity (FVC), the percentage of forced expiratory volume in the first second to the predicted value (FEV1%), and the percentage of PEFR in the predicted value (PEFR%) in the two groups were significantly increased compared with those before treatment (P < 0.05). After treatment, the levels of FVC, FEV1% and PEFR% in the treatment group were higher than those in the control group (P < 0.05). Conclusion Qingke Pingchuan Granules has good clinical effect in treatment of acute stage of bronchial asthma in children (heat asthma syndrome), and can significantly relieve cough, phlegm, wheezing and other symptoms in children, and also can improve lung function indicators.

R974

山東省科技發(fā)展計(jì)劃項(xiàng)目（2014GSF119005）