目的 觀察參貝北瓜膏聯(lián)合丙酸倍氯米松治療兒童哮喘急性發(fā)作期的臨床療效。方法 納入2021年1月—2022年6月唐山市工人醫(yī)院收治的160例哮喘急性發(fā)作期患兒為研究對(duì)象，按隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組各80例。對(duì)照組霧化吸入吸入用丙酸倍氯米松混懸液，2 mL/次，2次/d。治療組口服加用參貝北瓜膏，8 g/次，3次/d。兩組患兒治療14 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀改善時(shí)間，肺功能指標(biāo)第1秒用力呼氣末容積（FEV1）、最大肺活量（FVC）和FEV1/FVC水平，及炎癥因子指標(biāo)腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-4（IL-4）、干擾素-γ（INF-γ）、血清淀粉樣蛋白A（SAA）和半乳糖凝集素-3（Gal-3）水平。結(jié)果 治療后，治療組臨床治療有效率顯著高于對(duì)照組（96.25% vs 86.25%，P＜0.05）。治療后，治療組癥狀改善時(shí)間及住院時(shí)間均短于對(duì)照組（P＜0.05）。治療后，兩組FEV1、FVC與FEV1/FVC水平均高于治療前（P＜0.05），且治療組高于對(duì)照組（P＜0.05）。治療后，兩組TNF-α、IL-4、SAA和Gal-3水平均低于治療前，而INF-γ水平高于治療前（P＜0.05），且治療組患兒炎癥因子指標(biāo)水平明顯好于對(duì)照組（P＜0.05）。結(jié)論 參貝北瓜膏聯(lián)合丙酸倍氯米松治療哮喘發(fā)作期兒童的臨床療效更高，能夠更好的控制炎癥反應(yīng)，改善臨床癥狀。

Objective To observe the clinical efficacy of Shenbei Beigua Cream combined with beclomethasone propionate in treatment of children with bronchial asthma. Methods Children (160 cases) with bronchial asthma in Tangshan Workers' Hospital from January 2021 to June 2022 were divided into control and treatment group according to the random number table method, and each had 80 cases. Children in the control group was inhalation administered with Beclometasone Dipropionate Suspension for inhalation, 2 mL/time, twice daily. Children in the treatment group were po administered with Shenbei Beigua Cream on the basis of the control group, 8 g/time, three times daily. Children in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, the pulmonary function indexes of FEV1, FVC, and FEV1/FVC, inflammatory factor index of TNF-α, IL-4, SAA, Gal-3, and INF-γ in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (96.25% vs 86.25%, P < 0.05). After treatment, the symptom improvement time and hospital stay time in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the levels of FEV1, FVC and FEV1/FVC in two groups were higher than those before treatment (P < 0.05), and which in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels of TNF-α, IL-4, SAA, and Gal-3 in two groups were lower than those before treatment, while the level of INF-γ was higher than that before treatment (P < 0.05), and the level of inflammatory factors in the treatment group was significantly better than that in the control group (P < 0.05). Conclusion The clinical effect of Shenbei Beigua Cream combined with beclomethasone propionate in treatment of children with bronchial asthma is higher, which can better control the inflammatory reaction and improve the clinical symptoms.

R975;R985

河北省醫(yī)學(xué)科學(xué)研究課題（20191574）