阿爾茨海默病是最常見的老年進(jìn)行性神經(jīng)退行性疾病，藥物治療是阿爾茨海默病最常用的治療手段，目前臨床上只有少數(shù)藥物獲批。紅景天苷是紅景天中的主要活性成分，能夠通過降低β淀粉樣蛋白的神經(jīng)毒性、抑制神經(jīng)細(xì)胞凋亡、減輕神經(jīng)細(xì)胞氧化應(yīng)激和炎性損傷、延緩神經(jīng)元衰老、保護(hù)線粒體功能等多種機(jī)制發(fā)揮防治阿爾茨海默病的作用。因此綜述了紅景天苷防治阿爾茨海默病的作用機(jī)制，為紅景天苷的臨床研究提供參考。

Alzheimer's disease is the most common progressive neurodegenerative disease in the elderly. Drug treatment is the most commonly used treatment for Alzheimer's disease. At present, only a few drugs have been approved clinically. Salidroside is the main active ingredient in Rhodiolae Crenulatae Radix et Rhizoma. Salidroside can play a role in prevention and treatment of Alzheimer's disease through a variety of mechanisms, such as reducing β amyloid protein neurotoxicity, inhibition of neuronal apoptosis, reduction of oxidative stress and inflammatory damage of neurons, delay of neuronal aging, protection of mitochondrial function, etc. This article reviews the mechanism of salidroside in prevention and treatment of Alzheimer's disease, and provides reference for the clinical research of salidroside.

R971

河北省中醫(yī)藥管理局科研計(jì)劃項(xiàng)目（2021186）