心力衰竭是常見的臨床綜合征，其典型特征是高發(fā)病率、住院率和死亡率。人參皂苷Rb₁是人參中重要的活性成分之一，可通過抑制心肌細(xì)胞凋亡、抑制心肌肥大、調(diào)節(jié)心肌鈣離子濃度、提高心肌抗缺血作用、調(diào)節(jié)心肌細(xì)胞的自噬功能、改善心肌脂肪酸β氧化功能、調(diào)控磷脂酰肌醇3-激酶（PI3K）/蛋白質(zhì)激酶B（Akt）信號(hào)通路等多種作用機(jī)制對(duì)心力衰竭發(fā)揮防治作用，總結(jié)了人參皂苷Rb₁改善心力衰竭的作用機(jī)制，為人參皂苷Rb₁的臨床使用提供參考。

Heart failure is a common clinical syndrome, whose typical characteristics are high incidence rate, hospitalization rate, and mortality. Ginsenoside Rb₁ is one of the important active ingredients in Ginseng Radix, and can inhibit cardiomyocyte apoptosis, inhibit myocardial hypertrophy, regulate myocardial calcium concentration, improve myocardial anti ischemic effect, regulate autophagy function of myocardial cells, improve myocardial fatty acids β oxidation function, and regulate PI3K/Akt signal pathway to prevent and treat heart failure through various mechanisms. This paper summarizes the mechanism of ginsenoside Rb₁ in improving heart failure and provides reference for the clinical use of ginsenoside Rb₁.

R972

山東省醫(yī)藥衛(wèi)生科技發(fā)展計(jì)劃項(xiàng)目（202102080115）