目的 探討防風(fēng)通圣顆粒聯(lián)合糠酸莫米松乳膏治療過(guò)敏性皮炎的臨床療效。方法 選擇2019年3月—2021年10月唐山市中醫(yī)醫(yī)院收治的118例過(guò)敏性皮炎患者，按照隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組各59例。對(duì)照組外用糠酸莫米松乳膏，2次/d。在對(duì)照組的基礎(chǔ)上，治療組口服防風(fēng)通圣顆粒，3 g/次，2次/d。兩組治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀緩解時(shí)間，皮損面積，生活質(zhì)量評(píng)分，血清炎性因子腫瘤壞死因子-α（TNF-α）、γ干擾素（IFN-γ）、白細(xì)胞介素-13（IL-13）和IL-4水平及不良反應(yīng)情況。結(jié)果 治療后，治療組總有效率（98.31%）明顯高于對(duì)照組（83.05%，P＜0.05）。治療后，治療組癥狀緩解時(shí)間明顯短于對(duì)照組（P＜0.05）。治療后，兩組皮損面積評(píng)分、生活質(zhì)量評(píng)分均明顯低于治療前（P＜0.05），且治療組明顯低于對(duì)照組（P＜0.05）。治療后，兩組血清炎性因子IL-13、TNF-α、IL-4水平明顯下降，而IFN-γ水平明顯升高（P＜0.05）；且治療組明顯好于對(duì)照組（P＜0.05）。治療后，治療組不良反應(yīng)發(fā)生率為6.78%，明顯低于對(duì)照組（15.25%，P＜0.05)，結(jié)論 防風(fēng)通圣顆粒聯(lián)合糠酸莫米松乳膏治療過(guò)敏性皮炎療效確切，能減低機(jī)體炎性反應(yīng)狀態(tài)，并有效縮短癥狀緩解時(shí)間，且安全有效。

Objective To observe the efficacy for Fangfeng Tongsheng Granules combined with Mometasone Furoate Creams in treatment of allergic dermatitis. Methods Patients (118 cases) with allergic dermatitis in Tangshan Traditional Chinese Medicine Hospital from March 2019 to October 2021 were divided into control and treatment group by random number table, and each group had 59 cases. Patients in the control group were administered with Mometasone Furoate Creams, twice daily. Patients in the treatment group were po administered with Fangfeng Tongsheng Granules on the basis of the control group, 3 g/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, the relief time of symptom, the score of skin lesion area and quality of life, the levels of serum IL-13, TNF-α, IL-4 and IFN-γ, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (98.31%) was significantly higher than that of the control group (83.05%, P < 0.05). After treatment, the time of symptom relief in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the scores of skin lesion area and quality of life in two groups were significantly lower than those before treatment (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-13, TNF-α, and IL-4 in two groups were significantly decreased, while the level of IFN-γ were significantly increased (P < 0.05), and the serum inflammatory factors in the treatment group was significantly better than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group was 6.78%, which was significantly lower than that in the control group (15.25%, P < 0.05). Conclusion Fangfeng Tongsheng Granules combined with Mometasone Furoate Creams is effective in the treatment of allergic dermatitis, which can reduce the state of inflammatory reaction, and effectively shorten the time of symptom relief, and is safe and effective.

R986

河北省中醫(yī)藥管理局中醫(yī)藥科研課題計(jì)劃項(xiàng)目（2021389）