目的 探討小兒咳喘寧口服液聯(lián)合硫酸特布他林霧化吸入用溶液治療兒童急性支氣管炎的臨床療效。方法 選取2020年2月—2022年5月在漯河市中心醫(yī)院就診的84例急性支氣管炎患兒，根據(jù)隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組各42例。對(duì)照組患兒霧化吸入硫酸特布他林霧化吸入用溶液，體質(zhì)量≤20 kg，2.5 mg加入1 mL生理鹽水霧化吸入，體質(zhì)量＞20 kg， 5 mg加入2 mL生理鹽水霧化吸入，2次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服小兒咳喘寧口服液，3～4歲劑量5 mL/次，5歲及以上劑量10 mL/次，3次/d。兩組患兒連續(xù)治療7 d。觀察兩組的臨床療效，比較兩組患兒癥狀改善時(shí)間、血?dú)庵笜?biāo)、血清炎癥因子。結(jié)果 治療后，治療組的總有效率為95.24%，明顯高于對(duì)照組的總有效率80.95%，組間比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，治療組的體溫復(fù)常時(shí)間、止咳時(shí)間、肺啰音消失時(shí)間、咯痰消失時(shí)間均明顯短于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，兩組的血氧分壓、氧合指數(shù)高于治療前，二氧化碳總量低于治療前（P＜0.05）；治療組的血氧分壓、氧合指數(shù)高于對(duì)照組，二氧化碳總量低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，兩組的血清白細(xì)胞介素-2（IL-2）、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-8（IL-8）水平低于治療前（P＜0.05），且治療組的血清IL-2、TNF-α、IL-8水平低于對(duì)照組（P＜0.05）。結(jié)論 小兒咳喘寧口服液聯(lián)合硫酸特布他林霧化吸入用溶液治療兒童急性支氣管炎具有較好的臨床療效，能減輕臨床癥狀，改善血?dú)庵笜?biāo)，降低炎癥反應(yīng)，并且安全性良好。

Objective To investigate the clinical effect of Xiaoer Kechuanning Oral Liquid combined with Terbutaline Sulfate Nebuliser Solution in treatment of acute bronchitis in children. Methods Children (84 cases) with acute bronchitis in Luohe Central Hospital from February 2020 to May 2022 were divided into control and treatment groups according to the random number table method, and each group had 42 cases. Children in the control group were given aerosol inhalation of Terbutaline Sulfate Nebuliser Solution, the body mass ≤ 20 kg with 2.5 mg added into 1 mL normal saline, and the body mass above 20 kg with 5 mg added into 2 mL normal saline, twice daily. Children in the treatment group were po administered with Xiaoer Kechuanning Oral Liquid on the basis of the control group, with the dose 5 mL/time of 3-4 years old, and the dose 10 mL/time of above 5 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the symptom improvement time, the blood gas index, and the serum inflammatory factor levels in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.24%, significantly higher than that of the control group of 80.95%, and the difference was statistically significant (P < 0.05). After treatment, the temperature normalization time, cough relief time, rale disappearance time, and sputum disappearance time in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the partial pressure of blood oxygen and oxygenation index in two groups were higher than those before treatment, but the total amount of carbon dioxide in two groups was lower than that before treatment (P < 0.05). The partial pressure of blood oxygen and oxygenation index in the treatment group were higher than those in the control group, but the total amount of carbon dioxide in the treatment group was lower than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, the serum levels of IL-2, TNF-α, and IL-8 in the two groups were lower than those before treatment (P < 0.05), and the serum levels of IL-2, TNF-α, and IL-8 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Xiaoer Kechuanning Oral Liquid combined with Terbutaline Sulfate Nebuliser Solution has clinical curative effect in treatment of acute bronchitis in children, can alleviate clinical symptoms, improve blood gas indicators, reduce inflammatory reaction, with good safety.

R974;R985

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃（聯(lián)合共建）項(xiàng)目（LHGJ20191425）