目的 探討沙棘干乳劑聯(lián)合雙歧桿菌三聯(lián)活菌治療兒童功能性消化不良的臨床療效。方法 選取2021年5月—2022年7月在漯河市中心醫(yī)院就診的70例功能性消化不良患兒，依據(jù)隨機(jī)數(shù)字表法將所有患兒分為對照組和治療組，各35例。對照組口服雙歧桿菌三聯(lián)活菌膠囊，2次/d，2～5歲：1粒/次，5歲以上：2粒/次。治療組在對照組基礎(chǔ)上口服沙棘干乳劑，25 g/次，2次/d，沸水溶解攪拌，乳化后口服。兩組連續(xù)治療2周。觀察兩組患者臨床療效，比較兩組患者癥狀消失時(shí)間、胃腸功能指標(biāo)和血清指標(biāo)水平。結(jié)果 治療后，治療組的總有效率為97.14%，高于對照組的總有效率82.86%，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，治療組患兒惡心、腹脹、腹痛、噯氣消失時(shí)間短于對照組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，兩組的運(yùn)動指數(shù)、收縮頻率、收縮幅度明顯升高（P＜0.05），治療組患兒的運(yùn)動指數(shù)、收縮頻率、收縮幅度高于對照組（P＜0.05）。治療后，兩組的降鈣素基因相關(guān)肽（CGRP）、促腎上腺皮質(zhì)激素釋放因子（CRF）水平低于治療前，瘦素（LEP）水平高于治療前（P＜0.05）；治療組兒童的CGRP、CRF水平低于對照組，LEP水平高于對照組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。結(jié)論 沙棘干乳劑聯(lián)合雙歧桿菌三聯(lián)活菌治療兒童功能性消化不良的療效確切，能縮短癥狀消失時(shí)間，改善胃腸功能，調(diào)節(jié)CGRP、CRF、LEP的分泌。

Objective To investigate the clinical effect of Shaji Dry Emulsion combined with Lactobacillus and Enterococcus Capsules in treatment of functional dyspepsia in children. Methods Children (70 cases) with functional dyspepsia in Luohe Central Hospital from May 2021 to July 2022 were divided into control and treatment groups according to the random number table method, and each group had 35 cases. Children in the control group were po administered with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules, oral, twice daily, 2-5 years old: 1 grain/time, over 5 years old: 2 grains/time. Children in the treatment group were po administered with Shaji Dry Emulsion on the basis of the control group, dissolve and stir with boiling water, and taken orally after emulsification, 25 g/time, twice daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the symptom disappearance time, the gastrointestinal function indexes, and the serum indexes levels in two groups were compared. Results After treatment, the total effective rate of the treatment group was 97.14%, which was higher than that of the control group (82.86%), with a statistically significant difference (P < 0.05). After treatment, the disappearance times of nausea, abdominal distension, abdominal pain, and belching in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the exercise index, contraction frequency, and contraction amplitude of two groups were significantly higher than those before treatment (P < 0.05), and the exercise index, contraction frequency, and contraction amplitude of the treatment group were higher than those of the control group (P < 0.05). After treatment, the levels of CGRP and CRF in two groups were decreased, but the levels of LEP in two groups were increased (P < 0.05). The levels of CGRP and CRF in the treatment group were lower than those in the control group, while the levels of LEP were higher than those in the control group (P < 0.05). Conclusion Shaji Dry Emulsion combined with Bifidobacterium Triple Viable Bacteria has clinical curative effect in treatment of functional dyspepsia in children, can shorten the disappearance time of symptom, improve gastrointestinal function, and regulate the secretion of CGRP, CRF, and LEP.

R975;R985

河南中醫(yī)藥大學(xué)第一附屬醫(yī)院科研基金項(xiàng)目（2012KJ34）