目的 探討消石利膽膠囊聯(lián)合茴三硫片治療慢性膽囊炎的臨床療效。方法 選擇2021年3月—2022年3月在濮陽市中醫(yī)醫(yī)院治療的130例慢性膽囊炎患者，按照隨機(jī)數(shù)字表法分為對(duì)照組（65例）和治療組（65例）。對(duì)照組患者口服茴三硫片，1片/次，3次/d。在對(duì)照組的基礎(chǔ)上，治療組口服消石利膽膠囊，3粒/次，3次/d。兩組患者服藥8周。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀好轉(zhuǎn)時(shí)間，膽囊壁厚度積分，血清因子β-內(nèi)啡肽（β-EP）、白細(xì)胞介素-6（IL-6）、超氧化物歧化酶（SOD）和腫瘤壞死因子-α（TNF-α）水平及不良反應(yīng)。結(jié)果 治療后，治療組總有效率（98.46%）明顯高于對(duì)照組（84.62%，P＜0.05）。治療后，治療組出現(xiàn)的右上腹隱痛、惡心、腹脹、噯氣等癥狀好轉(zhuǎn)時(shí)間均明顯早于對(duì)照組（P＜0.05）。治療后，兩組B超膽囊壁厚度積分明顯低于治療前（P＜0.05），且治療組B超膽囊壁厚度積分明顯低于對(duì)照組（P＜0.05）。治療后，兩組血清因子IL-6、β-EP、TNF-α水平明顯降低，而SOD水平明顯升高（P＜0.05），且治療組血清因子水平明顯優(yōu)于對(duì)照組（P＜0.05）。治療后，治療組不良反應(yīng)發(fā)生率明顯低于對(duì)照組（P＜0.05）。結(jié)論 茴三硫片與消石利膽膠囊聯(lián)合治療慢性膽囊炎效果確切，可有效增加膽囊功能，并能使炎癥反應(yīng)減弱，患者癥狀好轉(zhuǎn)。

Objective To investigate the curative effect of Xiaoshi Lidan Capsules combined with anethole trithione in treatment of chronic cholecystitis. Methods Patients (130 cases) with chronic cholecystitis in Chinese Medicine Hospital of Puyang from March 2021 to March 2022 were randomly divided into control (65 cases) and treatment (65 cases) group. Patients in the control group were po administered with Anethole Trithione Tablets, 1 tablet/time, three times daily. Patients in the treatment group po administered with Xiaoshi Lidan Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, B-ultrasound gallbladder wall thickness integral, levels of serum factor IL-6, β-EP, TNF-α, and SOD, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (98.46%) was significantly higher than that of the control group (84.62%, P<0.05). After treatment, the improvement time of right upper abdominal pain, nausea, abdominal distension, belching and other symptoms in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the integral of gallbladder wall thickness in two groups was significantly lower than that before treatment (P<0.05), and the integral of gallbladder wall thickness of patients in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum levels of IL-6, β-EP, and TNF-α in two groups were significantly decreased, while the level of SOD were significantly increased (P<0.05), and the level of serum factors in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the incidence of adverse events in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion The combination of Xiaoshi Lidan Capsules and anethole trithione in treatment of chronic cholecystitis has a definite effect on chronic cholecystitis, which can effectively increase the gallbladder function, weaken the inflammatory reaction, and improve the symptoms of patients.

R975

河南省中醫(yī)藥科學(xué)研究課題（2018ZY3040）