目的 探討鹽酸氨酮戊酸聯(lián)合聚甲酚磺醛治療尖銳濕疣的臨床療效。方法 選擇2021年4月—2022年4月在南陽市中心醫(yī)院治療的98例尖銳濕疣女性患者，根據(jù)用藥的差別分為對照組和治療組，每組各49例。對照組給予聚甲酚磺醛栓，置入陰道內(nèi)，1枚/次，隔日1次。在此基礎(chǔ)上，治療組給予鹽酸氨酮戊酸外用散，配成20%的溶液，每隔30分鐘敷用1次，持續(xù)敷藥3h，用氦氖激光照射，每周1次。兩組連續(xù)治療4周。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀改善時間，CECA10評分、GSES評分、FS-36評分和NRS評分，血清可溶性白細(xì)胞介素-2受體（sIL-2R）、γ干擾素（IFN-γ）、白細(xì)胞介素-18（IL-18）、粒細(xì)胞-巨噬細(xì)胞集落刺激因子（GM-CSF）、白細(xì)胞介素-23（IL-23）和低氧誘導(dǎo)因子-1α（HIF-1α）水平。結(jié)果 治療后，治療組總有效率為97.96%，顯著高于對照組（83.67%，P<0.05）。治療后，疣狀物消失、外陰瘙癢、外陰疼痛、惡臭味等癥狀消失時間均早于對照組（P<0.05）。治療后，兩組CECA10評分、GSES評分、FS-36評分均明顯升高，而NRS評分明顯下降（P<0.05），并且治療組評分明顯好于對照組（P<0.05）。治療后，兩組患者血清sIL-2R、IL-18、GM-CSF、HIF-1α水平明顯降低，而IIFN-γ和IL-23水平明顯升高（P<0.05），且治療組細(xì)胞因子水平明顯好于對照組（P<0.05）。結(jié)論 鹽酸氨酮戊酸聯(lián)合聚甲酚磺醛治療尖銳濕疣可有效改善患者癥狀，降低炎癥反應(yīng)，提高性生活質(zhì)量及自我效能水平。

Objective To explore the clinical efficacy of aminolevulinic acid hydrochloride combined with Policresulen Suppositories in treatment of condyloma acuminatum.Methods Female patients (98 cases) with condyloma acuminatum in Nanyang Central Hospital from April 2021 to April 2022 were divided into control and treatment group based on different treatments, and each group had 49 cases. Patients in the control group were administered with Policresulen Suppositories, 1 suppository at a time in the vagina, once every other day. Patients in the treatment group were administered with Aminolevulinic Acid Hydrochloride Topical Powder on the basis of the control group, prepared 20% solution, applied every 30 min for 3 h, irradiated by He-Ne laser, once weekly. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, the scores of CECA10, GSES, FS-36 and NRS, the levels of cytokine sIL-2R, IL-18, GM-CSF, HIF-1α, IIFN-γ, and IL-23 in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 97.96%, significantly higher than that of the control group (83.67%, P < 0.05). After treatment, the disappearance time of warts, vulvar pruritus, vulvar pain, odor and other symptoms were earlier than those of the control group (P < 0.05). After treatment, the CECA10 score, GSES score, and FS-36 score in two groups were significantly increased, while the NRS score were significantly decreased (P< 0.05), and these scores in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the serum levels of sIL-2R, IL-18, GM-CSF and HIF-1α in two groups were significantly decreased, while the levels of IIFN-γ and IL-23 were significantly increased (P< 0.05), and the cytokine level in the treatment group was significantly better than that in the control group (P < 0.05). Conclusion Aminolevulinic acid hydrochloride combined with Policresulen Suppositories in treatment of condyloma acuminatum can effectively improve the symptoms of patients, reduce the inflammatory reaction, and improve the quality of sexual life and self-efficacy.

R984

河南省醫(yī)學(xué)科技攻關(guān)計劃普項目（LHGJ20200905）