目的 分析替雷利珠單抗不良反應(yīng)的臨床表現(xiàn)和特點(diǎn)，為臨床安全用藥提供參考。方法 檢索中國知網(wǎng)、萬方、維普、PubMed、Embase、Web of Science等數(shù)據(jù)庫有關(guān)替雷利珠單抗導(dǎo)致不良反應(yīng)的文獻(xiàn)報(bào)道，并進(jìn)行整理分析。結(jié)果 共收集到替雷利珠單抗導(dǎo)致不良反應(yīng)的文獻(xiàn)報(bào)道17篇，18例患者，其中男性13例（72.2%）、女性5例（27.8%），年齡分布在60歲以上居多（72.2%），發(fā)生時(shí)間大多在用藥后3個(gè)月內(nèi)（72.2%），替雷利珠單抗致不良反應(yīng)以皮膚及其附件損害最多見（6例，33.3%），17例經(jīng)停藥和對癥治療好轉(zhuǎn)，1例因繼發(fā)肺部感染死亡。結(jié)論 替雷利珠單抗致不良反應(yīng)累及多個(gè)器官/系統(tǒng)，應(yīng)增強(qiáng)監(jiān)測，防范嚴(yán)重不良反應(yīng)的發(fā)生，確保用藥安全。

Objective The characteristics and relative factors of adverse drug reactions induced by tislelizumab were analyzed, in order to provide reference for the clinical use of tislelizumab properly. Methods Case reports of adverse drug reactions induced by tislelizumab were searched and analyzed from the databases of CNKI, Wanfang, VIP, PubMed, Embase, and Web of Science. Results A total of 17 articles were included with 18 cases, involving 13 males (72.2%) and 5 females (27.8%). The incidence of adverse drug reactions in patients aged over 60 years old was the highest (72.2%), adverse drug reactions induced by tislelizumab frequently occurred within 3 months (72.2%), Organs/systems involved in adverse drug reactions were mainly skin system (6 case, 33.3%). 17 cases were improved after drug withdrawal and symptomatic treatment, and 1 case died due to secondary pulmonary infection. Conclusion Clinicians and pharmacists should pay attention to the adverse drug reactions of tislelizumab, so as to prevent the occurrence of serious adverse drug reactions and ensure the safety of drug use.

R979.1