目的 探討鹿胎膏聯(lián)合地屈孕酮片治療月經(jīng)不調(diào)的臨床療效。方法 選取2021年3月—2022年3月在天津市中心婦產(chǎn)科醫(yī)院進(jìn)行治療的104例月經(jīng)不調(diào)患者為研究對(duì)象，依據(jù)用藥差別將所有患者分為對(duì)照組和治療組，每組各52例。對(duì)照組患者口服地屈孕酮片，從月經(jīng)周期的第11～25天，10 mg/次，2次/d；治療組患者在對(duì)照組基礎(chǔ)上口服鹿胎膏，10 g/次，2次/d。兩組均治療2個(gè)月經(jīng)周期。觀察兩組患者的臨床療效，比較兩組相關(guān)量表評(píng)分、臨床癥狀改善時(shí)間、性激素水平。結(jié)果 治療后，治療組總有效率是98.08%，顯著高于對(duì)照組的82.69%（P＜0.05）。治療后，兩組中華生存質(zhì)量量表（ChQOL）評(píng)分、HPS評(píng)分、卡氏功能狀態(tài)（KPS）評(píng)分均較治療前顯著升高，月經(jīng)失血圖（PBAC）評(píng)分顯著降低（P＜0.05）；治療后，治療組ChQOL評(píng)分、HPS評(píng)分、KPS評(píng)分高于對(duì)照組，而PBAC評(píng)分低于對(duì)照組（P＜0.05）。經(jīng)治療，治療組經(jīng)行腹痛、頭暈眼花、腰骶酸軟、胃寒肢冷、五心煩熱、少言懶語(yǔ)等癥狀改善時(shí)間均顯著短于對(duì)照組（P＜0.05）。治療后，兩組血清卵泡生成激素（FSH）、催乳素（PRL）、黃體生成激素（LH）均較治療前顯著降低，而雌二醇（E₂）顯著升高，治療后，治療組性激素水平改善優(yōu)于對(duì)照組（P＜0.05）。結(jié)論 鹿胎膏聯(lián)合地屈孕酮片治療月經(jīng)不調(diào)具有較好的臨床療效，可有效改善患者臨床癥狀，調(diào)整性激素水平，有助于改善患者生活質(zhì)量，值得臨床推廣應(yīng)用。

Objective To explore the clinical effect of Lutai Ointment combined with dydrogesterone in treatment of irregular menstruation. Methods A total of 104 patients with irregular menstruation treated in Tianjin Central Obstetrics and Gynecology Hospital from March 2021 to March 2022 were selected as the research objects. According to the difference in medication, all patients were divided into control group and treatment group, with 52 cases in each group. Patients in the control group were po administered with Dydrogesterone Tablets, from the 11th to 25th day of the menstrual cycle, 10 mg/time, twice daily. Patients in the treatment group were po administered with Lutai Ointment on the basis of the control group, 10 g/time, twice daily. Both groups were treated for 2 menstrual cycles. The clinical efficacy of the two groups were observed, and the scores of related scales, improvement time of clinical symptoms and sex hormone levels of the two groups were compared. Results After treatment, the total effective rate of treatment group was 98.08%, significantly higher than that of control group 82.69% (P < 0.05). After treatment, the scores of Chinese Quality of Life Scale (ChQOL), HPS and Carsten function status (KPS) in two groups were significantly increased compared with before treatment, while the score of menstrual blood loss map (PBAC) was significantly decreased (P < 0.05). After treatment, ChQOL score, HPS score and KPS score in the treatment group were higher than those in the control group, while PBAC score was lower than that in the control group (P < 0.05). After treatment, the improvement time of symptoms such as abdominal pain, dizziness, lumbosacral softness, stomach cold and limb cold, five upset fever, less speech and lazy language in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, serum follicle-forming hormone (FSH), prolactin (PRL) and luteinizing hormone (LH) in two groups were significantly decreased compared with before treatment, while estradiol (E₂) was significantly increased. After treatment, the level of sex hormone in treatment group was better than that in control group (P < 0.05).Conclusion Lutai Ointment combined with dydrogesterone has a significant effect in treatment of irregular menstruation, and can effectively improve the clinical symptoms of patients, adjust the level of sex hormones, help to improve the quality of life of patients, which is worthy of clinical application.

R984

天津市衛(wèi)生健康科研項(xiàng)目(KJ20047)