糖尿病是一種代謝紊亂型疾病，恢復(fù)胰島素敏感性和改善代謝穩(wěn)態(tài)對治療糖尿病及其并發(fā)癥至關(guān)重要。小檗堿可緩解胰島素抵抗，降低血糖。總結(jié)了小檗堿通過依賴性蛋白激酶（MAPK）信號通路、胰島素信號通路、核因子-κB（NF-κB）信號通路以及其他信號通路改善胰島素抵抗來說明小檗堿降血糖的作用機制。

Diabetes is a metabolic disorder. Restoring insulin sensitivity and improving metabolic homeostasis are critical for the treatment of diabetes and its complications. Berberine can relieve insulin resistance and lower blood sugar. This paper summarizes the mechanism of berberine's hypoglycemic effect by improving insulin resistance through MAPK signaling pathway, insulin signaling pathway, NF-κB signaling pathway, and other signaling pathways.

R285

國家自然科學(xué)基金資助項目（82174274，81803995）