目的 探討三唑類(lèi)抗真菌藥物致急性胰腺炎不良反應(yīng)的臨床特點(diǎn)、發(fā)生機(jī)制及防治措施，為臨床合理用藥提供參考。方法 檢索三唑類(lèi)抗真菌藥物自上市以來(lái)國(guó)內(nèi)外發(fā)表的關(guān)于其引起急性胰腺炎不良反應(yīng)的文獻(xiàn)，按照患者性別、年齡、飲酒史、用藥情況、不良反應(yīng)發(fā)生的時(shí)間、臨床表現(xiàn)及處理方法等進(jìn)行統(tǒng)計(jì)分析。結(jié)果 共納入8篇文獻(xiàn)，涉及11例患者，18歲以下兒童所占比例最高（36.36%）。不良反應(yīng)發(fā)生時(shí)間最短的為用藥12 h，最長(zhǎng)的為用藥10周后，停藥或減量或更換藥品后不良反應(yīng)癥狀可痊愈或好轉(zhuǎn)。結(jié)論 三唑類(lèi)抗真菌藥物致急性胰腺炎不良反應(yīng)需引起醫(yī)務(wù)人員重視，尤其是應(yīng)用于兒童時(shí)。建議臨床在應(yīng)用三唑類(lèi)抗真菌藥物時(shí)，嚴(yán)格按照說(shuō)明書(shū)的推薦劑量和療程給藥，并密切監(jiān)測(cè)患者是否出現(xiàn)急性胰腺炎的癥狀。

Objective To investigate the clinical characteristics, mechanism, prevention and treatment of adverse reactions of acute pancreatitis caused by triazole antifungal drugs, so as to provide reference for clinical rational drug use. Methods To search the literatures about the adverse reactions of acute pancreatitis caused by triazole antifungal drugs that have been published at home and abroad since they were listed on the market. Statistical analysis was carried out according to the patient's gender, age, drinking history, medication, time of adverse reactions, clinical manifestations and treatment methods. Results A total of 8 literatures were included, involving 11 patients. The proportion of children under 18 years old was the highest (36.36%). The shortest time for adverse reactions to occur is 12 h after medication, and the longest is 10 weeks after medication. The symptoms of adverse reactions can be cured or improved after stopping or reducing the dose or changing the drug. Conclusion The adverse reactions of acute pancreatitis caused by triazole antifungal drugs should be paid attention to by medical staff, especially when used in children. It is suggested that the clinical application of triazole antifungal drugs should be strictly in accordance with the recommended dose and course of treatment in the manual, and patients should be closely monitored for symptoms of acute pancreatitis.

R978.5