塞來昔布是一種特異性環(huán)氧化酶-2抑制劑，具有抗炎、鎮(zhèn)痛和退熱作用。近年來，塞來昔布的抗腫瘤作用受到廣泛關注，已被應用于消化道腫瘤、乳腺癌、肺癌、肝癌、前列腺癌等的化學輔助治療和放射治療增敏。綜述了塞來昔布的抗腫瘤效應，并總結了其作用機制，如抑制腫瘤細胞增殖、抑制腫瘤細胞侵襲和轉移、抑制腫瘤新生血管生成、誘導腫瘤細胞分化、誘導腫瘤細胞凋亡、調節(jié)腫瘤免疫、逆轉腫瘤細胞的多藥耐藥性，以期為塞來昔布的深入研究和臨床腫瘤防治提供用藥參考。

Celecoxib is a specific cyclooxygenase-2 inhibitor, and has anti-inflammatory, analgesic, and antipyretic effects. In recent years, the antitumor effect of celecoxib has received extensive attention, and has been applied to adjuvant chemotherapy and radiotherapy for gastrointestinal cancer, breast cancer, lung cancer, liver cancer, prostate cancer, and so on. This article reviews the antitumor effect of celecoxib and summarizes its mechanism, such as inhibiting tumor cell proliferation, inhibiting tumor cell invasion and metastasis, inhibiting tumor angiogenesis, inducing tumor cell differentiation, inducing tumor cell apoptosis, regulating tumor immunity, and reversing multidrug resistance of tumor cells, in order to provide drug reference for further research and clinical tumor prevention and treatment of celecoxib.

R979.1

國家自然科學基金資助項目(81803101);天津市自然科學基金資助項目(19JCQNJC12300)