目的 分析抗感染藥物不良反應(yīng)（ADR）發(fā)生的特點(diǎn)，為臨床安全用藥提供依據(jù)。方法 對咸陽市中心醫(yī)院2016年1月—2021年12月上報(bào)的317例抗感染藥物不良反應(yīng)進(jìn)行回顧性分析。結(jié)果 老年患者（36.28%）最易發(fā)生ADR；靜脈滴注（89.27%）ADR發(fā)生率最高；ADR主要發(fā)生在用藥31～60 min；引起ADR最多的藥物為頭孢類，其次是喹諾酮類；ADR的臨床表現(xiàn)以皮膚及附件系統(tǒng)損害最多見。結(jié)論 醫(yī)院重視抗感染藥物的管理，提高用藥合理性，加強(qiáng)用藥監(jiān)測，有效降低不良反應(yīng)的發(fā)生率。

Objective The characteristics of anti-infective adverse drug reactions (ADR) were analyzed to provide evidence for clinical safty drug use. Methods A retrospective research method was conducted to analyze 317 ADR reports in Xianyang Central Hospital from January 2016 to December 2021. Results The elderly patients (36.28%) had the highest incidence of ADR. The incidence of ADR was highset in intravenous drip (89.27%). The most ADR occurred between 31 — 60 min. Cephalosporins caused most ADR, followed by quinolones. The most common clinical manifestations of ADR were skin and accessory lesions. Conclusion In clinical work, medical workers should pay attention to the management of anti-infective drugs, improve the rationality of drug use, strengthen the drug use monitoring, and effectively reduce the probability of adverse reactions.

R978.1