目的 探討復(fù)明片聯(lián)合曲伏前列素滴眼液治療開(kāi)角型青光眼的臨床療效。方法 選取2017年10月—2021年1月在洛陽(yáng)市第三人民醫(yī)院眼科治療的142例開(kāi)角型青光眼患者，根據(jù)隨機(jī)數(shù)字法將所有患者分為對(duì)照組和治療組，每組各組71例。對(duì)照組外用曲伏前列素滴眼液，睡前1滴/次，1次/d。治療組在對(duì)照組治療基礎(chǔ)上口服復(fù)明片，5片/次，3次/d。兩組連續(xù)用藥30 d。觀察兩組的臨床療效，比較兩組臨床癥狀緩解情況，眼動(dòng)脈血流指標(biāo)和血清學(xué)因子水平。結(jié)果 治療后，治療組總有效率是98.59%，顯著高于對(duì)照組的84.51%（P＜0.05）。治療后，治療組視力模糊、眼脹、視力下降、頭痛緩解時(shí)間均顯著短于對(duì)照組（P＜0.05）。治療后，兩組眼動(dòng)脈血流阻力指數(shù)（RI）、動(dòng)脈收縮期最大流速（PSV）均較治療前顯著降低，但舒張末期血流速度（EDV）顯著升高（P＜0.05）；治療后，治療組眼動(dòng)脈血流指標(biāo)改善優(yōu)于對(duì)照組（P＜0.05）。治療后，兩組患者血清白細(xì)胞介素-6（IL-6）、白細(xì)胞介素-1β（IL-1β）、干擾素-γ（IFN-γ）、內(nèi)皮素-1（ET-1）水平均較治療前顯著降低（P＜0.05）；治療后，治療組血清因子水平低于對(duì)照組（P＜0.05）。結(jié)論 復(fù)明片聯(lián)合曲伏前列素滴眼液治療開(kāi)角型青光眼具有較好的臨床療效，可明顯改善眼部血流指標(biāo)，能有效降低眼部炎癥狀態(tài)，值得臨床推廣使用。

Objective To investigate the therapeutic effect of Fuming Tablets combined with Travoprost Eye Drops in treatment of open-angle glaucoma. Methods A total of 142 cases of open-angle glaucoma treated in Luoyang Third People’s Hospital from October 2017 to January 2021 were selected. All patients were divided into control group and treatment group according to random number method, with 71 cases in each group. Patients in the control group were given Travoprost Eye Drops, 1 drop/time before bedtime, once daily. Patients in the control group were po administered with Fuming Tablets on the basis of the control group, 5 tablets/time, 3 times daily. Both groups were treated for 30 d. The clinical efficacy of the two groups was observed, and the clinical symptom relief, ocular artery blood flow index and serological factor levels were compared between the two groups. Results After treatment, the total effective rate in the treatment group was 98.59%, significantly higher than that in the control group (84.51%, P < 0.05). After treatment, the relief time of blurred vision, eye distension, decreased vision, and headache in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the blood flow resistance index (RI) and the maximum systolic flow rate (PSV) were significantly decreased, but the end diastolic flow velocity (EDV) was significantly increased in two groups (P < 0.05). After treatment, the improvement of blood flow index of ocular artery in treatment group was better than that in control group (P < 0.05). After treatment, the levels of serum interleukin-6 (IL-6), interleukin-1 β (IL-1β), interferon-γ(IFN-γ), and endothelin-1 (ET-1) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the level of serum factors in the treatment group was better than that in the control group (P < 0.05). Conclusion Fuming Tablets combined with Travoprost Eye Drops has good clinical effect in treatment of open-angle glaucoma, and can obviously improve the blood flow index of the eye and effectively reduce the inflammatory state of the eye, which is worthy of clinical application.

R988.1

河南省衛(wèi)建委課題(WjLx2020539)