目的 探討小兒柴桂退熱顆粒聯(lián)合頭孢呋辛酯治療小兒急性上呼吸道感染的臨床效果。方法 選取2020年5月-2021年4月駐馬店市中心醫(yī)院婦女兒童醫(yī)院收治的207例急性上呼吸道感染患兒,使用隨機數(shù)字表法分成對照組(103例)和治療組(104例)。對照組口服頭孢呋辛酯膠囊,0.125 g/次,2次/d。在對照組基礎上,治療組口服小兒柴桂退熱顆粒,1~3歲患兒5 g/次、4~6歲7.5 g/次、7~12歲10 g/次,4次/d。兩組患兒均連續(xù)治療5 d。觀察兩組患者臨床療效,比較治療前后兩組患者退熱效果,主要癥狀消失時間,外周血白細胞計數(shù)(WBC),及血清降鈣素原(PCT)、淀粉樣蛋白A(SAA)、白細胞介素-8(IL-8)和腫瘤壞死因子-α(TNF-α)水平。結果 治療后,治療組總有效率為94.2%,較對照組的81.6%顯著升高(P<0.05)。治療后,治療組即刻退熱率為49.0%,顯著高于對照組的32.0%(P<0.05),治療組退熱起效時間和體溫復常時間均顯著短于對照組(P<0.05)。治療后,治療組鼻塞、流涕和咽部紅腫消失時間較對照組均顯著縮短(P<0.05)。治療后,兩組外周血WBC及血清PCT、SAA、IL-8和TNF-α水平均顯著下降(P<0.05),且治療組降低作用較對照組更顯著(P<0.05)。結論 小兒柴桂退熱顆粒聯(lián)合頭孢呋辛酯對急性上呼吸道感染患兒具有確切的臨床療效,可安全有效且迅速地緩解患兒癥狀,退熱效果顯著,并能抑制炎癥反應。

Objective To investigate the clinical effect of Xiaoer Chaigui Tuire Granules combined with cefuroxime axetil in treatment of children with acute upper respiratory tract infection. Methods Children (207 cases) with acute upper respiratory tract infection in Women and Children Hospital, Zhumadian Central Hospital from May 2020 to April 2021 were divided into control (103 cases) and treatment (104 cases) group by the random number table method. Children in the control group were po administered with Cefuroxime Axetil Capsules, 0.125 g/time, twice daily. Children in the treatment group were po administered with Xiaoer Chaigui Antipyretic Granules on the basis of the control group, 5 g/time for 1 — 3 years old, 7.5 g/time for 4 — 6 years old, 10 g/time for 7 — 12 years old, four times daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, the effect of antipyretic, the disappearance time of main symptoms, the levels of WBC and serum PCT, SAA, IL-8, and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 94.2%, which was significantly higher than 81.6% in the control group (P < 0.05). After treatment, the immediate antipyretic rate in the treatment group was 49.0%, which was significantly higher than 32.0% in the control group (P < 0.05), and the onset time of antipyretic and the recovery time of body temperature in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, time for nasal congestion, runny nose and pharyngeal redness to disappear in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the concentration of the peripheral blood WBC and serum PCT, SAA, IL-8, and TNF-α in two groups were significantly decreased (P < 0.05), and the decreasing effect of the treatment more significant than that of the control group (P < 0.05). Conclusion Xiaoer Chaigui Tuire Granules combined with cefuroxime axetil in treatment of children with acute upper respiratory tract infection has definite clinical effect, can safely, effectively and quickly alleviate the symptoms, has significant antipyretic effect, and can inhibit inflammatory reaction.

R974