目的 探討丹青膠囊聯(lián)合他扎羅汀倍他米松治療銀屑病的臨床療效。方法 選取2019年6月—2021年6月在天津市職業(yè)病防治院門診皮膚科就診治療的114例銀屑病患者，根據(jù)隨機(jī)數(shù)字法分為對(duì)照組和治療組，每組各57例。對(duì)照組患者給予他扎羅汀倍他米松乳膏，洗凈患處，待皮膚干爽后，將適量本品均勻涂抹于患處，1次/d。治療組患者在對(duì)照組治療基礎(chǔ)上口服丹青膠囊，4粒/次，3次/d。兩組患者均連續(xù)治療7 d。觀察兩組患者的臨床療效和臨床癥狀好轉(zhuǎn)時(shí)間，比較兩組治療前與治療1、4、8周的皮損面積和嚴(yán)重程度指數(shù)（PASI）評(píng)分和血清炎性因子水平。結(jié)果 治療后，治療組總有效率是98.25%，顯著高于對(duì)照組的82.46%（P<0.05）。治療后，治療組患者皮損暗紅、皮損肥厚、皮膚瘙癢、皮膚疼痛等癥狀好轉(zhuǎn)時(shí)間均顯著短于對(duì)照組（P<0.05）。治療后，兩組PASI評(píng)分均較治療前顯著降低（P<0.05）；治療1、4、8周治療組PASI評(píng)分顯著低于對(duì)照組（P<0.05）。治療后，兩組患者血清炎性因子白細(xì)胞介素6（IL-6）、白細(xì)胞介素17（IL-17）、腫瘤壞死因子α（TNF-α）、干擾素-γ（IFN-γ）水平均較治療前顯著降低（P<0.05）；治療后，治療組血清炎性因子水平顯著低于對(duì)照組（P<0.05）。結(jié)論 丹青膠囊聯(lián)合他扎羅汀倍他米松治療銀屑病效果明顯，能顯著降低炎性因子水平，并有助于改善皮損情況，值得臨床推廣應(yīng)用。

Objective To investigate the efficacy of Danqing Capsules combined with tazarotene and betamethasone in treatment of psoriasis. Methods Methods a total of 114 patients with psoriasis treated in dermatology department of Tianjin Occupational Disease Prevention and Control Hospital from June 2019 to June 2021 were selected and divided into control group and treatment group according to random number method, with 57 cases in each group. Patients in the control group were given Tazarotene and Betamethasone Dipropionate Cream, washed the affected area, after the skin was dry, evenly applied appropriate amount of this product to the affected area, once daily. Patients in the treatment group were po administered with Danqing Capsules on the basis of the control group, 4 grains/time, three times daily. Both groups were treated for 7 d. The clinical efficacy and improvement time of clinical symptoms in two groups were observed, and the score of skin lesion area and severity index (PASI) and the level of serum inflammatory factors were compared between two groups before treatment and 1, 4, and 8 weeks after treatment. Results After treatment, the total effective rate of the treatment group was 98.25%, significantly higher than that of the control group (82.46%) (P < 0.05). After treatment, the improvement time of dark red skin, skin hypertrophy, skin pruritus, and skin pain in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, PASI score in both groups was significantly lower than that before treatment (P < 0.05). PASI score in treatment group was significantly lower than control group at 1, 4, and 8 weeks after treatment (P < 0.05). After treatment, serum levels of inflammatory cytokines interleukin-6 (IL-6), interleukin-17 (IL-17), tumor ecrosis factor α (TNF-α) and interferon -γ (IFN-γ) in two groups were significantly decreased compared with before treatment. After treatment, the level of serum inflammatory factors in treatment group was significantly lower than that in control group (P < 0.05). Conclusion Danqing Capsules combined with tazarotene and betamethasone has obvious effect in treatment of psoriasis, and can significantly reduce the level of inflammatory factors and help to improve skin lesions, which is worthy of clinical application.

R986

天津市科委重點(diǎn)攻關(guān)項(xiàng)目（CSTC2017AB5032）