目的 探討勝紅清熱片聯(lián)合青霉素鈉治療慢性盆腔炎的臨床療效。方法 選擇2020年5月—2021年5月在河南大學淮河醫(yī)院治療96例慢性盆腔炎患者，根據(jù)用藥的差別分為對照組和治療組，每組各48例。對照組靜脈滴注注射用青霉素鈉，800萬U/次，2次/d；治療組在對照組基礎上口服勝紅清熱片，4片/次，3次/d。兩組患者經2周治療。觀察兩組患者臨床療效，比較治療前后兩組證候改善時間，血清白細胞介素-1β（IL-1β）、白細胞介素-26（IL-26）、單核細胞趨化蛋白1（MCP-1）、粒細胞-巨噬細胞集落刺激因子（GM-CSF）和降鈣素原（PCT）水平，及子宮動脈血流動力參數(shù)血管搏動指數(shù)（PI）和血管阻力指數(shù)（RI）和收縮期峰流速度（Vs）。結果 經治療，對照組和治療組患者總有效率分別為83.33%和97.92%，兩組比較差異有統(tǒng)計學意義（P<0.05）。經治療，治療組證候改善時間明顯短于對照組（P<0.05）。經治療，兩組血清IL-1β、IL-26、MCP-1、GM-CSF和PCT水平均明顯下降（P<0.05），且治療組降低更明顯（P<0.05）。經治療，兩組患者子宮動脈血流動力參數(shù)PI、RI、Vs明顯升高（P<0.05），且治療組顯著高于對照組（P<0.05）。結論 勝紅清熱片聯(lián)合青霉素鈉治療慢性盆腔炎在改善臨床癥狀的同時還具有降低機體促炎因子水平和促進子宮動脈血流動力學改善的作用。

Objective To investigate the clinical efficacy of Shenghong Qingre Tablets combined with penicillin sodium in treatment of chronic pelvic inflammatory disease. Methods Patients (96 cases) with chronic pelvic inflammatory disease in Huaihe Hospital of Henan University from May 2020 to May 2021 were divided into control and treatment group according to different treatments, and each group had 48 cases. Patients in the control group were iv administered with Benzylpenicillin sodium for injection, 8 million U/time, twice daily. Patients in the treatment group were po administered with Shenghong Qingre Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, the levels of serological indexes IL-1β, IL-26, MCP-1, GM-CSF and PCT, and the hemodynamic parameters of uterine artery of PI, RI and Vs in two groups before and after treatment were compared. Results After treatment, the effective rates of the control group and the treatment group were 83.33% and 97.92% respectively (P < 0.05). After treatment, the improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of serum IL-1 β, IL-26, MCP-1, GM-CSF and PCT were significantly decreased in two groups (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the uterine artery hemodynamic parameters PI, RI and Vs in two groups were significantly increased (P < 0.05), and which in the treatment group were significantly higher than those in the control group (P< 0.05). Conclusion Shenghong Qingre Tablets combined with penicillin sodium in treatment of chronic pelvic inflammatory disease can not only improve the clinical symptoms, but also reduce the level of pro-inflammatory factors and promote the improvement of uterine artery hemodynamics.

R984

河南省高等學校重點科研項目計劃（17A320023）