目的 探討二維三七桂利嗪膠囊聯(lián)合依達(dá)拉奉治療腦梗死的臨床效果。方法 選擇2019年1月—2019年12月天津市寧河區(qū)醫(yī)院收治的80例腦梗死患者，根據(jù)信封法分為對(duì)照組和治療組，每組各40例。對(duì)照組靜脈滴注依達(dá)拉奉注射液，30 mg依達(dá)拉奉注射液加入100 mL生理鹽水，2次/d。治療組在對(duì)照組的基礎(chǔ)上口服二維三七桂利嗪膠囊，1粒/次，1次/d。兩組連續(xù)治療2周。觀察兩組患者臨床療效，比較治療前后兩組患者日常生活能力（ADL）、美國(guó)國(guó)立衛(wèi)生研究所卒中量表（NIHSS）評(píng)分，腦動(dòng)脈血流速度及血管內(nèi)皮功能和炎癥因子水平。結(jié)果 治療后，治療組總有效率明顯高于對(duì)照組（P<0.05）。治療后，兩組患者ADL評(píng)分升高，而NIHSS評(píng)分明顯降低（P<0.05），且治療組評(píng)分明顯好于對(duì)照組（P<0.05）。治療后，兩組患者大腦中動(dòng)脈、大腦前動(dòng)脈、大腦后動(dòng)脈的血流速度明顯加快，且治療組明顯快于對(duì)照組（P<0.05）；治療后，兩組一氧化氮（NO）明顯升高，而超敏C反應(yīng)蛋白（hs-CRP）、腫瘤壞死因子-α（TNF-α）、內(nèi)皮素1（ET-1）明顯降低（P<0.05），且治療組血管內(nèi)皮功能和炎癥因子水平明顯好于對(duì)照組（P<0.05）。結(jié)論 二維三七桂利嗪膠囊聯(lián)合依達(dá)拉奉治療腦梗死具有較好的臨床療效，在改善神經(jīng)功能、腦動(dòng)脈血流速度、生活自理能力方面效果顯著，其主要作用機(jī)制可能與調(diào)節(jié)炎癥、血管內(nèi)皮功能有關(guān)。

Objective To investigate the clinical effect of Divitamins, Notoginseng and Cinnarizine Capsules combined with edaravone in treatment of ischemic cerebral infarction. Methods Patients (80 cases) with ischemic cerebral infarction in Ninghe District Hospital from January 2019 to December 2019 were divided into control and treatment group according to envelope method, and each group had 40 cases. Patients in the control group were iv administered with Edaravone Injection, 30 mg added into 100 mL normal saline, twice daily. Patients in the treatment group were po administered with Divitamins, Notoginseng and Cinnarizine Capsules on the basis of the control group, 1 grain/time, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical evaluation was evaluated, the scores of ADL and NIHSS, the cerebral arterial blood flow velocity, and the vascular endothelial function and inflammatory factors in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, ADL was significantly increased in two groups, but NIHSS were decreased (P < 0.05), and these scores in the treatment group was significantly better than those in the control group (P < 0.05). After treatment, the blood flow velocity of middle cerebral artery, anterior cerebral artery and posterior cerebral artery in two groups was significantly increased (P < 0.05), which in the treatment group was significantly faster than that in the control group (P < 0.05). After treatment, NO level was significantly increased in two groups, but the level of hs-CRP, TNF-α, ET-1 were significantly decreased (P < 0.05), and the vascular endothelial function and inflammatory factors in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Divitamins, Notoginseng and Cinnarizine Capsules combined with edaravone in treatment of ischemic cerebral infarction has a significant effect on improving neurological function, cerebral arterial blood flow velocity and self-care ability, and the main mechanism may be related to the regulation of inflammation and vascular endothelial function.

R971

天津市科技計(jì)劃項(xiàng)目（15ZXMFCY00062）