偏頭痛是一種臨床常見的原發(fā)性頭痛疾病，其發(fā)病率、致殘率逐年升高，給患者、家庭和社會帶來沉重負(fù)擔(dān)。目前偏頭痛發(fā)病機制尚不明確。有研究表明壓力、睡眠障礙等與偏頭痛周期性發(fā)作有密切聯(lián)系。褪黑激素在臨床上廣泛應(yīng)用，尤其在其節(jié)律性減少或失調(diào)有關(guān)的疾病中，如晝夜節(jié)律性睡眠障礙、阿爾茨海默病等。偏頭痛患者被證明存在時間生物學(xué)功能障礙，并且褪黑激素被證明具有抗炎、抗氧化、抗焦慮、鎮(zhèn)痛等作用，因此對褪黑激素治療偏頭痛的作用機制和臨床應(yīng)用研究進(jìn)展進(jìn)行概括，以期為偏頭痛的防治提供參考。

Migraine is a common clinical primary headache disease. Its incidence and disability rate are increasing year by year, which brings a heavy burden to patients, families, and society. At present, the pathogenesis of migraine is still unclear. Studies have shown that stress, sleep disturbance, etc. are closely related to the periodic attacks of migraine. Melatonin is widely used in clinics, especially in diseases related to its rhythmic reduction or imbalance, such as circadian rhythm sleep disorder, Alzheimer's disease, and so on. Patients with migraine have been proved to have chronobiological dysfunction, and melatonin has been shown to have anti- inflammatory, antioxidant, anti-anxiety, and analgesic effects. This article discusses the mechanism and clinical application of melatonin in treatment of migraine, which provides reference for the prevention and treatment of migraine.

R971

山東省醫(yī)藥衛(wèi)生科技發(fā)展計劃項目（2019WS322）