目的 觀察小兒咳喘靈泡騰顆粒聯(lián)合吸入用布地奈德混懸液治療小兒喘息性肺炎的臨床療效。方法 選取2018年8月—2021年2月河南科技大學(xué)第一附屬醫(yī)院收治的126例小兒喘息性肺炎，根據(jù)入院就診順序單雙號將所有患者分為對照組和治療組，每組各63例。對照組患兒霧化吸入吸入用布地奈德混懸液，1 mg/次，2次/d。治療組在對照組的基礎(chǔ)上口服小兒咳喘靈泡騰顆粒，2次/d，5~7歲為2 g，2~4歲為1.5 g，＜2歲者為1 g。兩組患兒均治療2周。觀察兩組治療后的療效，比較兩組患兒癥狀消失時(shí)間、血清免疫因子和血清炎性因子。結(jié)果 治療后，治療組的總有效率為90.48%，高于對照組的總有效率71.43%，組間對比存在統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，治療組咳嗽、氣促、喘息、濕啰音、哮鳴音消失時(shí)間均明顯短于對照組（P＜0.05）。治療后，兩組患兒嗜酸粒細(xì)胞陽離子蛋白（ECP）、嗜酸粒細(xì)胞（EoS）水平較治療前降低（P＜0.05），且治療組ECP、EoS水平低于對照組（P＜0.05）。治療后，兩組白細(xì)胞介素-6（IL-6）、C反應(yīng)蛋白（CRP）水平較治療前降低，γ-干擾素（TNF-γ）水平較治療前升高（P＜0.05）；治療后治療組IL-6、CRP水平低于對照組，TNF-γ水平高于對照組（P＜0.05）。結(jié)論 小兒咳喘靈泡騰顆粒聯(lián)合吸入用布地奈德混懸液治療小兒喘息性肺炎具有較好的臨床療效，可明顯改善臨床癥狀，減輕氣道炎癥反應(yīng)。

Objective To observe the clinical effect of Xiaoer Kechuanling Effervescent Granules combined with Budesonide Suspension for inhalation in treatment of asthmatic pneumonia in children.Methods Children (126 cases) with asthmatic pneumonia in the First Affiliated Hospital of Henan University of Science and Technology from August 2018 to February 2021 were divided into control and treatment groups according to the order of the odd and even numbers of admission, and each group had 63 cases. Patients in the control group were atomization inhalation with Budesonide Suspension for inhalation, 1 mg/time, twice daily. Patients in the treatment group were po administered with Xiaoer Kechuanling Effervescent Granules on the basis of the control group, 2 g for 5 — 7 years old, 1.5 g for 2 — 4 years old, and 1 g for < 2 years old, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance time of symptoms, the serum immune factors, and the serum inflammatory factors in two groups were compared.Results After treatment, the total effective rate of the treatment group was 90.48%, which was higher than 71.43% of the control group, and there was significant difference between two groups (P < 0.05). After treatment, the disappearance time of cough, short-breath, wheezing, wet rale, and wheezing sound in the treatment group was significantly shorter than those in the control group (P < 0.05). After treatment, the levels of ECP and EoS in two groups were lower than those before treatment (P < 0.05), and the levels of ECP and EoS in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of IL-6 and CRP in two groups were lower than those before treatment, but the level of TNF-γ in two groups was higher than that before treatment (P < 0.05). After treatment, the levels of IL-6 and CRP in the treatment group were lower than those in the control group, but the level of TNF-γ was higher than that in the control group (P < 0.05).Conclusion Xiaoer Kechuanling Effervescent Granules combined with Budesonide Suspension for inhalation has clinical curative effect in treatment of asthmatic pneumonia in children, can significantly improve clinical symptoms and reduce airway inflammatory response.

R974

河南省科技發(fā)展計(jì)劃項(xiàng)目（182102311201）