目的 探討茵陳五苓糖漿聯(lián)合人血白蛋白治療新生兒高膽紅素血癥的臨床療效。方法 選取2019年4月—2021年4月在南陽市中心醫(yī)院治療的98例高膽紅素血癥患兒，隨機分為對照組（49例）和治療組（49例）。對照組靜脈滴注人血白蛋白，10 g加入5%葡萄糖注射液100 mL，1次/d。治療組患者在對照組基礎上口服茵陳五苓糖漿，10 mL/次，3次/d。兩組患者連續(xù)用藥5 d。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀好轉時間，血總膽紅素（TBIL）和血間接膽紅素（IBIL）水平，血清炎性因子白細胞介素-8（IL-8）、白細胞介素-6（IL-6）、腫瘤壞死因子（TNF-α）和C反應蛋白（CRP）水平，及不良反應情況。結果 治療后，治療組患兒臨床有效率明顯高于對照組（97.96% vs 79.59%，P＜0.05）。治療后，治療組臨床癥狀好轉時間明顯早于對照組（P＜0.05）。治療后，兩組患兒TBIL、IBIL水平，及血清炎性因子IL-8、IL-6、TNF-α、CRP水平明顯低于治療前（P＜0.05），且治療組顯著低于對照組（P＜0.05）。結論 茵陳五苓糖漿與人血白蛋白聯(lián)合治療能顯著提高臨床有效率，有效降低膽紅素及炎性反應，臨床癥狀改善明顯，藥物不良反應減少。

Objective To investigate the curative effect of Yinchen Wuling Syrup combined with human albumin in treatment of neonatal hyperbilirubinemia.Methods Children (98 cases) with neonatal hyperbilirubinemia in Nanyang Central Hospital from April 2019 to April 2021 were randomly divided into control (49 cases) and treatment (49 cases) group. Children in the control group were iv administered with Human Albumin, 10 g added into 5% glucose injection 100 mL, once daily. Children in the treatment group were po administered with Yinchen Wuling Syrup on the basis of the control group, 10 mL/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, serum bilirubin levels of TBIL and IBIL, levels of serum inflammatory factor IL-8, IL-6, TNF-α, and CRP, and adverse reactions in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (97.96% vs 79.59%, P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of TBIL and IBIL, and serum inflammatory factors IL-8, IL-6, TNF- α and CRP in two groups were significantly lower than those before treatment, and these factors in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion Yinchen Wuling Syrup combined with Human Albumin in treatment of neonatal hyperbilirubinemia can significantly improve the clinical effective rate, effectively reduce bilirubin and inflammatory reaction, improve clinical symptoms and reduce adverse drug reactions.

R973

河南省醫(yī)學科技攻關計劃（2018020618）