目的 探討天舒膠囊聯(lián)合氟桂利嗪治療前庭性偏頭痛的臨床效果。方法 選取2019年1月—2021年6月天津市第三中心醫(yī)院分院中醫(yī)科診治的120例前庭性偏頭痛患者，按隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組各60例。對(duì)照組患者口服鹽酸氟桂利嗪膠囊，10 mg/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服天舒膠囊，4粒/次，3次/d。兩組療程均為12周，隨訪期為8周。觀察兩組的臨床療效，比較兩組眩暈視覺(jué)模擬評(píng)分（VAS）、臨床癥狀、眩暈障礙量表（DHI）和腦血流速度。結(jié)果 治療后，治療組明顯改善率是73.3%，明顯高于對(duì)照組的33.3%（P＜0.05）。治療后，兩組VAS評(píng)分均顯著降低，眩暈平均每月發(fā)作次數(shù)與持續(xù)時(shí)間均顯著減少（P＜0.05）；治療后，治療組VAS評(píng)分和臨床癥狀改善均優(yōu)于對(duì)照組（P＜0.05）。治療后，兩組軀體評(píng)分、情緒評(píng)分、功能評(píng)分及DHI總分均顯著降低（P＜0.05）；治療后，治療組DHI評(píng)分顯著低于對(duì)照組（P＜0.05）。治療后，兩組大腦椎動(dòng)脈（VA）和基底動(dòng)脈（BA）的平均血流速度均顯著降低（P＜0.05）；治療后，治療組VA和BA的平均血流速度均低于對(duì)照組（P＜0.05）。結(jié)論 天舒膠囊聯(lián)合氟桂利嗪治療前庭性偏頭痛療效良好，可改善臨床癥狀，縮減發(fā)作頻率及發(fā)作時(shí)間，在軀體及情緒維度提升患者生活質(zhì)量，值得臨床推廣。

Objective To investigate the effect of Tianshu Capsules combined with flunarizine in treatment of vestibular migraine.Methods A total of 120 patients with vestibular migraine treated in the Department of Traditional Chinese Medicine of Tianjin Third Central Hospital Branch from January 2019 to June 2021 were selected and divided into control group and treatment group according to random number table method, with 60 cases in each group. Patients in the control group were po administered with Flunarizine Hydrochloride Capsules, 10 mg/time, once daily. Patients in the treatment group were po administered with Tianshu Capsules on the basis of the control group, 4 grains/time, three times daily. The treatment course of both groups was 12 weeks, and the follow-up period was 8 weeks. After treatment, the clinical efficacy was evaluated, visual analogue scale (VAS), clinical symptoms, vertigo disorder scale (DHI) and cerebral blood flow velocity were compared between the two groups.Results After treatment, the improvement rate of the treatment group was 73.3%, which was significantly higher than that of the control group (33.3%, P < 0.05). After treatment, VAS scores were significantly decreased in both groups, and the average number and duration of vertigo attacks per month were significantly decreased in both groups (P < 0.05). After treatment, VAS score and clinical symptoms in the treatment group were better than those in the control group (P < 0.05). After treatment, body score, mood score, functional score, and DHI total score in two groups were significantly decreased (P < 0.05). After treatment, DHI score in treatment group was significantly lower than that in control group (P < 0.05). After treatment, the mean blood flow velocity of cerebral vertebral artery (VA) and basilar artery (BA) was significantly decreased in both groups (P < 0.05). After treatment, the average blood flow velocity of VA and BA in treatment group was lower than that in control group (P < 0.05).Conclusion Tianshu Capsules combined with flunarizine has good efficacy in treatment of vestibular migraine, and can improve clinical symptoms, reduce the frequency and duration of attacks, and improve the life quality of patients in physical and emotional dimensions, which is worthy of clinical promotion.

R971

國(guó)家中醫(yī)藥管理局國(guó)家中醫(yī)臨床研究基地業(yè)務(wù)建設(shè)科研專項(xiàng)課題（JDZX2015020）