目的 探究多糖鐵復合物膠囊治療孕婦妊娠期缺鐵性貧血的臨床療效。方法 選取2018年4月—2020年11月天津醫(yī)科大學總醫(yī)院濱海醫(yī)院收治的352例缺鐵性貧血孕婦，所有患者按照隨機數(shù)表法分為對照組和治療組，每組各176例。對照組口服琥珀酸亞鐵片，2片/次，3次/d。治療組口服多糖鐵復合物膠囊，2粒/次，1次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效，比較兩組治療前后的血常規(guī)指標、鐵代謝相關指標以及兩組孕婦妊娠結局、不良反應發(fā)生情況。結果 治療后，治療組的總有效率（95.45%）顯著高于對照組（87.50%）（P<0.05）。治療后，兩組紅細胞計數(shù)（RBC）、紅細胞壓積（HCT）、血紅蛋白（Hb）均顯著提高（P<0.05）；且治療組RBC、HCT、Hb顯著高于對照組（P<0.05）。治療后，兩組血清鐵（SI）、血清鐵蛋白（SF）均顯著提高（P<0.05）；且治療組SI、SF顯著高于對照組（P<0.05）。治療后，治療組不良妊娠結局發(fā)生率（14.20%）顯著低于對照組（22.73%）（P<0.05）。治療期間，治療組不良反應發(fā)生率（5.11%）顯著低于對照組（12.50%）（P<0.05）。結論 多糖鐵復合物膠囊治療妊娠期缺鐵性貧血療效顯著，可明顯改善孕婦血常規(guī)指標，改善母嬰結局，安全性較好。

Objective To investigate the effect of Iron Polysaccharide Complex Capsules in treatment of iron deficiency anemia during pregnancy. Methods Pregnant woman (352 cases) with iron deficiency anemia in Binhai Hospitial of General Hospital Affiliated to Tianjin Medical University from April 2018 to November 2020 were randomly divided into control and treatment groups, and each group had 176 cases. Patients in the control group were po administered with Ferrous Succinate Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Iron Polysaccharide Complex Capsules on the basis of the control group, 2 grains/time, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the blood routine indexes, the related indexes of iron metabolism, the pregnancy outcomes, and the adverse reactions in two groups were compared. Results After treatment, the total effective rate of the treatment group (95.45%) was significantly higher than that of the control group (87.50%) (P < 0.05). After treatment, the RBC, HCT, and Hb in two groups were significantly increased (P < 0.05). After treatment, the RBC, HCT, and Hb in the treatment group were significantly higher than those in the control group (P< 0.05). After treatment, the SI and SF in two groups were significantly increased (P < 0.05), and the SI and SF in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the incidence of adverse pregnancy outcomes in the treatment group (14.20%) was significantly lower than that in the control group (22.73%) (P < 0.05). During the treatment period, the incidence of adverse reactions in the treatment group (5.11%) was significantly lower than that in the control group (12.50%) (P< 0.05). Conclusion Iron Polysaccharide Complex Capsules has clinical curative effect in treatment of iron deficiency anemia during pregnancy, can improve the blood routine indexes, and improve the maternal and infant outcomes, with good safety.

R984