目的 探討齒痛消炎靈顆粒聯(lián)合鹽酸米諾環(huán)素軟膏治療慢性牙周炎的臨床療效。方法 選取2018年2月—2021年5月在武警河南總隊(duì)醫(yī)院治療的124例慢性牙周炎患者，根據(jù)隨機(jī)數(shù)字表法將患者分為對照組和治療組，每組各62例。對照組給予鹽酸米諾環(huán)素軟膏治療，注滿患部牙周袋內(nèi)，以溢出為宜，1次/周。治療組在對照組治療基礎(chǔ)上口服齒痛消炎靈顆粒，10 g/次，3次/d。兩組均連續(xù)治療4周。觀察兩組臨床療效，比較兩組牙周指標(biāo)、血清炎癥指標(biāo)。結(jié)果 治療后，對照組的總有效率為72.58%，明顯低于治療組的91.94%（P<0.05）。治療后，兩組出血指數(shù)（BI）、牙周袋深度（PD）、牙齦指數(shù)（GI）、齦溝出血指數(shù)（SBI）、菌斑指數(shù)（PLI）較同組治療前降低（P<0.05），且治療組BI、PD、GI、SBI、PLI明顯低于對照組（P<0.05）。治療后，兩組白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、高遷移率族蛋白B（HMGB）水平較同組治療前降低（P<0.05），且治療組IL-6、TNF-α、HMGB水平明顯低于對照組（P<0.05）。結(jié)論 齒痛消炎靈顆粒聯(lián)合鹽酸米諾環(huán)素軟膏可有效改善慢性牙周炎患者的臨床癥狀，抑制炎癥因子水平分泌，安全性較好。

Objective To investigate the clinical effect of Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment in treatment of chronic periodontitis. Methods Patients (124 cases) with chronic periodontitis in Henan Armed Police Corps Hospital from February 2018 to May 2021 were randomly divided into control and treatment groups, and each group had 62 cases. Patients in the control group were given Minocycline Hydrochloride Ointment, filled the affected periodontal pocket, and overflow, once daily. Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the periodontal indexes and serum inflammatory indexes in two groups were compared. Results After treatment, the total effective rate in the control group was 72.58%, which was significantly lower than 91.94% in the treatment group (P < 0.05). After treatment, the BI, PD, GI, SBI, and PLI in two groups were lower than those in the same group before treatment (P < 0.05), and the BI, PD, GI, SBI, and PLI in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of IL-6, TNF-α, and HMGB in two groups were lower than those in the same group before treatment (P < 0.05), and the levels of IL-6, TNF-α, and HMGB in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment can effectively improve the clinical symptoms of patients with chronic periodontitis, and inhibit the secretion of inflammatory factors, with good safety.

R988.2

河南省重點(diǎn)研發(fā)與推廣專項(xiàng)項(xiàng)目（212102310593）