目的 探討銀杏葉片聯(lián)合倍他司汀治療良性陣發(fā)性位置性眩暈手法復(fù)位后殘留癥狀的臨床效果。方法 選取2019年1月—2020年8月天津中醫(yī)藥大學(xué)第一附屬醫(yī)院收治的120例良性陣發(fā)性位置性眩暈患者經(jīng)成功手法復(fù)位后仍有殘留癥狀者，采取隨機(jī)數(shù)字表法將隨機(jī)分成對(duì)照組（n=60）和治療組（n=60）。對(duì)照組口服甲磺酸倍他司汀片，6 mg/次，3次/d。治療組在對(duì)照組基礎(chǔ)上口服銀杏葉片，1片/次，3次/d。兩組均連續(xù)治療7 d。觀察兩組的臨床療效，比較兩組頭暈、平衡障礙的緩解時(shí)間、前庭癥狀指數(shù)（VSI）、頭暈殘障問卷（DHI）總分及焦慮自評(píng)量表（SAS）、抑郁自評(píng)量表（SDS）評(píng)分及半年復(fù)發(fā)率。結(jié)果 治療后，治療組總有效率是96.7%，較對(duì)照組的81.7%顯著提高（P<0.05）。治療后，治療組頭暈緩解時(shí)間、平衡障礙緩解時(shí)間均顯著短于對(duì)照組（P<0.05）。兩組治療后VSI總分、DHI總分、SAS評(píng)分、SDS評(píng)分均顯著降低（P<0.05）；且治療后，治療組相關(guān)量表評(píng)分低于對(duì)照組（P<0.05）。隨訪6個(gè)月，治療組復(fù)發(fā)率為8.3%，較對(duì)照組21.7%顯著降低（P<0.05）。結(jié)論 銀杏葉片聯(lián)合倍他司汀對(duì)良性陣發(fā)性位置性眩暈經(jīng)成功手法復(fù)位后仍有殘余癥狀患者具有確切的臨床療效，可安全有效且迅速地改善患者殘留癥狀，并對(duì)患者焦慮及抑郁癥狀亦有顯著的改善作用，是提高患者生活質(zhì)量、降低復(fù)發(fā)風(fēng)險(xiǎn)的良好途徑，值得臨床推廣應(yīng)用。

Objective To investigate the clinical effect of Yinxingye Tablets combined with betahistine in treatment of residual symptoms of benign paroxysmal positional vertigo after manual reduction. Methods A total of 120 patients with benign paroxysmal positional vertigo admitted to First Teaching Hospial of Tianjin University of Traditional Chinese Medicine from January 2019 to August 2020 who still had residual symptoms after successful manual reduction were randomly divided into control group (n=60) and treatment group (n=60) by random number table method. Patients in the control group were po administered with Betahistine Mesilate Tablets, 6 mg/time, three times daily. Patients in the treatment group were po administered with Yinxingye Tablets on the basis of the control group, 1 tablet/time, three times daily. Both groups were treated for 7 d. The clinical efficacy of the two groups were observed, and the remission time of dizziness and balance disorder, vestibular symptom Index (VSI), total score of dizzy disability Questionnaire (DHI), self-rating Anxiety Scale (SAS), self-rating depression Scale (SDS) and half-year recurrence rate of the two groups were compared. Results After treatment, the total effective rate in the treatment group was 96.7%, significantly higher than that in the control group (81.7%) (P<0.05). After treatment, the relief time of dizziness and balance disorder in treatment group was significantly shorter than that in control group (P<0.05). VSI total score, DHI total score, SAS score, and SDS score were significantly decreased in 2 groups after treatment (P<0.05). After treatment, the scores of related scales in the treatment group were lower than those in the control group (P<0.05). After 6 months of follow-up, the recurrence rate in the treatment group was 8.3%, significantly lower than that in the control group (21.7%) (P<0.05). Conclusion Yinxingye Tablets combined with betahistine has a definite overall effect in treatment of residual symptoms of benign paroxysmal positional vertigo after manual reduction, and can safely, effectively and rapidly improve the residual symptoms of patients, and also significantly improve the symptoms of anxiety and depression of patients, which is a good way to improve the quality of life of patients and reduce the risk of recurrence, worthy of clinical application.

R971