目的 探討阿膠強骨口服液聯合骨化三醇膠丸治療老年骨質疏松的臨床療效。方法 選取2019年3月—2021年3月在安康市人民醫(yī)院就診治療的128例老年骨質疏松患者，根據隨機數字法將128例老年骨質疏松患者分為對照組（n=64）和治療組（n=64）。對照組口服骨化三醇膠丸，1粒/次，2次/d。治療組在對照組的基礎上口服阿膠強骨口服液，10 mL/次，3次/d。兩組患者均連續(xù)服用藥物3個月。觀察兩組的臨床療效，比較兩組臨床癥狀好轉時間、骨代謝指標和骨密度的變化。結果 治療后，治療組患者總有效率是98.44%，顯著高于對照組的84.38%（P<0.05）。治療組患者腰酸背痛好轉時間、骨骼疼痛好轉時間、下肢無力好轉時間、肌肉痙攣好轉時間均顯著短于對照組（P<0.05）。治療后，兩組Ⅰ型膠原羧基端交聯肽（CTX）、血清Ⅰ型膠原氨基端前肽（P1NP）均顯著降低，但25-羥基維生素D[25（OH） D]、骨鈣素（BGP）升高（P<0.05）；治療后，治療組骨代謝指標改善優(yōu)于對照組（P<0.05）。治療后，兩組患者股骨頸骨骨密度、腰椎骨骨密度、股骨大轉子骨密度均較治療前顯著升高（P<0.05）；治療后，治療組骨密度改善優(yōu)于對照組（P<0.05）。結論 阿膠強骨口服液聯合骨化三醇膠丸治療老年骨質疏松臨床療效顯著，能有效改善骨密度，增強骨代謝功能，值得臨床推廣應用。

Objective To investigate the curative effect of Ejiao Qianggu Oral Liquid combined with Calcitriol Capsules in treatment of senile osteoporosis. Methods A total of 128 elderly patients with osteoporosis treated in Ankang People’s Hospital from March 2019 to March 2021 were selected. According to the random number method, 128 elderly patients with osteoporosis were divided into control group (n=64) and treatment group (n=64). Patients in the control group were po administered with Calcitriol Soft Capsules, 1 grain/time, twice daily. Patients in the treatment group were po administered with Ejiao Qianggu Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Both groups were given drugs for 3 months. The clinical efficacy of the two groups were observed, and the improvement time of clinical symptoms, bone metabolism index, and bone mineral density were compared between the two groups. Results After treatment, the total effective rate in treatment group was 98.44%, significantly higher than that in control group (84.38%) (P<0.05). The improvement time of back pain, bone pain, lower limb weakness, and muscle spasm in treatment group was significantly shorter than that in control group (P<0.05). After treatment, CTX and P1NP were significantly decreased, but 25(OH)D and BGP were increased in both groups (P<0.05). After treatment, the improvement of bone metabolism index in treatment group was better than that in control group (P<0.05). After treatment, bone mineral density of femoral neck, lumbar vertebra and greater trochanter in two groups were significantly increased compared with before treatment (P<0.05). After treatment, BMD in the treatment group was better than that in the control group (P<0.05). Conclusion Ejiao Qianggu Oral Liquid combined with calcitriol has significant clinical effect in treatment of senile osteoporosis, and can effectively improve bone mineral density and enhance bone metabolism, which is worthy of clinical application.

R982

陜西省重點研發(fā)計劃項目（20175F-197）