目的 優(yōu)化柴銀顆粒的水煎煮工藝。方法 以出膏率、連翹苷轉(zhuǎn)移率為考察指標，以加水量、煎煮次數(shù)和煎煮時間為考察因素，在單因素試驗基礎上運用Box-Behnken響應面法進行優(yōu)化，確定最佳工藝條件，并進行驗證。結(jié)果 優(yōu)化后的工藝為煎煮3次，每次加水11倍量，煎煮1.5 h。結(jié)論 Box-Behnken響應面優(yōu)化的煎煮工藝可用于柴銀顆粒的提取。

Objective To optimize the extraction technology of Chaiyin Granules. Methods Taking paste rates and transfer rate of forsythin as index, volume fractions of water, extraction times, and extraction time as factors, based on single factor experiment, Box-Behnken design-response surface method was used to optimize the extraction technology of Chaiyin Granules. The verification tests were carried out on the optimized extraction technology. Results The optimal extraction technology included that 11 times of water, 3 extraction times, and extracting for 1.5 h each time. Conclusion Box-Behnken response surface methodology can be used to optimize the extraction technology of Chaiyin Granules .

R284.2

山東省重點研發(fā)計劃（重大科技創(chuàng)新工程）項目（2020CXGC010505）