目的 培養(yǎng)左氧氟沙星單晶，進行結(jié)構(gòu)表征。方法 用乙腈–水體系培養(yǎng)單晶，并用單晶X射線衍射儀（SXRD）檢測分析。結(jié)果 制備得到左氧氟沙星無色片狀晶體，該晶胞屬于單斜晶系，空間群為P2₁，分子式為C₁₈H₂₀FN₃O₄·H₂O，相對分子質(zhì)量為379.38，晶體密度為1.469 mg/mm³，絕對構(gòu)型為S構(gòu)型。結(jié)論 實驗證明了左氧氟沙星的立體構(gòu)型，培養(yǎng)的晶體晶型為一水合物。

Objective To cultivate single crystal of levofloxacin, and to characterize the structure of Levofloxacin. Methods Cultivate single crystals with acetonitrile-water system, and single crystal X-ray diffractometer (SXRD) was used to detect and analyze. Results Levofloxacin colorless acicular crystal was obtained, and SXRD confirmed the monoclinic lattice with space group P2₁ in levofloxacin. The chemical formula and relative molecular mass were C₁₈H₂₀FN₃O₄·H₂O and 379.38, and crystal density was 1.469 mg/mm³, absolute configuration was S style. Conclusion crystal structure of levofloxacin is characterized, and the crystal form of the cultured crystal is levofloxacin monohydrate.

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