目的 探討新鄭市人民醫(yī)院婦科腫瘤術(shù)后發(fā)生醫(yī)院感染的病原菌情況。方法 選取2015年9月-2020年9月在新鄭市人民醫(yī)院接受婦科腫瘤手術(shù)的120例患者的治療資料進(jìn)行分析。結(jié)果 婦科腫瘤術(shù)120例患者總計(jì)檢出病原菌208株，革蘭陰性菌134株（64.42%），革蘭陽(yáng)性菌60株（28.85%），真菌14株（6.73%）。大腸埃希菌耐藥性較高的藥物依次為頭孢曲松（59.09%）、復(fù)方新諾明（56.82%）、環(huán)丙沙星（54.55%），對(duì)替加環(huán)素為0。肺炎克雷伯菌耐藥性較高的藥物依次為阿莫西林（71.42%）、頭孢曲松（42.86%）、頭孢噻肟（39.29%），最低為替加環(huán)素（3.57%）。銅綠假單胞菌耐藥性較高的藥物依次為頭孢曲松（81.25%）、復(fù)方新諾明（81.25%）、阿莫西林（68.75%）。鮑氏不動(dòng)桿菌耐藥性較高的藥物依次為亞胺培南（100%）、哌拉西林（92.86%）、頭孢吡肟（85.71%）。從主要革蘭陽(yáng)性菌對(duì)抗菌藥物的耐藥性來(lái)看，金黃色葡萄球菌對(duì)氨芐西林（90.00%）、復(fù)方新諾明（90.00%）耐藥率較高。表皮葡萄球菌對(duì)青霉素（81.82%）、四環(huán)素（81.82%）耐藥率較高。結(jié)論 婦科腫瘤手術(shù)后感染的發(fā)生與多種病原菌有關(guān)，主要為革蘭陰性菌，不同病原菌的耐藥性存在差異，臨床治療方案需要全面評(píng)估感染情況，保證用藥方案的科學(xué)合理，并注重監(jiān)測(cè)，結(jié)合病原學(xué)證據(jù)及時(shí)調(diào)整治療方案。

Objective To investigate the pathogenic bacteria of nosocomial infection after gynecological tumor operation in Xinzheng People's Hospital. Methods The treatment data of 120 patients undergoing gynecological tumor surgery in Xinzheng People's Hospital from September 2015 to September 2020 were analyzed. Results A total of 208 strains of pathogenic bacteria were detected from 120 patients undergoing gynecological tumor surgery, including 134 strains of gram-negative bacteria (64.42%), 60 strains of gram-positive bacteria (28.85%), and 14 strains of fungi (6.73%). The drug resistance of Escherichia coli was ceftriaxone (59.09%), cotrimoxazole (56.82%), ciprofloxacin (54.55%), and the drug resistance of tigecycline was 0. The drugs with high drug resistance of Klebsiella pneumonia were amoxicillin (71.42%), ceftriaxone (42.86%), cefotaxime (39.29%), and the lowest was tigecycline (3.57%). The drugs with high resistance to Pseudomonas aeruginosa were ceftriaxone (81.25%), cotrimoxazole (81.25%), and amoxicillin (68.75%). The drugs with high resistance to Acinetobacter baumannii were imipenem (100%), piperacillin (92.86%), and cefepime (85.71%). In terms of antimicrobial resistance of main gram-positive bacteria, Staphylococcus aureus had higher drug resistance rates to ampicillin (90.00%) and cotrimoxazole (90.00%). The resistance rates of Staphylococcus epidermidis to benzylpenicillin (81.82%) and tetracycline (81.82%) were higher. Conclusions The occurrence of infection after gynecological tumor surgery is related to a variety of pathogens, mainly gram-negative bacteria, and there are differences in drug resistance of different pathogens. The clinical treatment plan needs to be comprehensively evaluated to ensure the scientific and reasonable drug use plan, pay attention to monitoring, and adjust the treatment plan in time combined with etiological evidence.

R978.1