目的 分析天津市安定醫(yī)院住院患者服用抗精神分裂藥物所致不良反應(yīng)（ADR）的情況與特點(diǎn)，為臨床合理用藥提供參考依據(jù)。方法 對(duì)2017年1月-2020年12月天津市安定醫(yī)院主動(dòng)上報(bào)至國(guó)家不良反應(yīng)監(jiān)測(cè)中心的與抗精神分裂癥藥品相關(guān)的88例ADR報(bào)告進(jìn)行分析。結(jié)果 產(chǎn)生ADR的患者中31~40歲年齡段占比最高，致ADR藥物排名前3的為利培酮、奧氮平、氨磺必利，不良反應(yīng)時(shí)間大于14 d的案例最多，ADR累及多個(gè)器官和系統(tǒng)，主要涉及神經(jīng)精神系統(tǒng)和心腦血管，抗精神分裂藥物ADR臨床表現(xiàn)多見(jiàn)于患者產(chǎn)生錐體外系反應(yīng)。結(jié)論 目前臨床應(yīng)用的抗精神分裂藥物致ADR發(fā)生的幾率仍然存在，需要加強(qiáng)患者用藥期間監(jiān)測(cè)，根據(jù)實(shí)際情況動(dòng)態(tài)優(yōu)化用藥方案，降低不良反應(yīng)發(fā)生率。

Objective To analyze the situation and characteristics of adverse reactions (ADR) caused by antischizophrenic drugs in Tianjin Anding Hospital, and to provide reference for rational drug use in clinic. Methods To analyze 88 ADR reports related to antischizophrenia drugs voluntarily reported to National Adverse reaction Monitoring Center by Tianjin Anding Hospital in from January 2017 to December 2020. Results The proportion of ADR patients aged from 31 to 40 was the highest. The top 3 ADR causing drugs were risperidone, olanzapine, and aminosulpiride. The adverse reaction time longer than 14 days was the most common. ADR involves multiple organs and systems, mainly involving the neuropsychiatric system and cardiovascular and cerebrovascular systems. The clinical manifestations of antischizophrenic ADR are more common in patients with extrapyramidal reactions. Conclusion At present, the incidence rate of ADR caused by antischizophrenia drugs still exists in clinical application, so it is necessary to strengthen the monitoring of patients during medication, dynamically optimize medication regimen according to the actual situation, and reduce the incidence of adverse reactions.

R971