目的 探討美托洛爾聯(lián)合阿托伐他汀鈣治療冠心病心絞痛的臨床效果。方法 選取2019年1月-2020年12月高州市人民醫(yī)院收治的冠心病心絞痛患者80例為研究對象，所有患者隨機分為對照組和治療組，每組各40例。對照組口服阿托伐他汀鈣片，20 mg/次，1次/d，根據(jù)個體差異不同適當增加藥物劑量，每天總劑量勿超過80 mg。治療組在對照組基礎(chǔ)上口服琥珀酸美托洛爾緩釋片，23.75 mg/次，1次/d，每日最大劑量不超過100 mg。兩組均持續(xù)服用6個月。觀察兩組的臨床療效，比較兩組心絞痛發(fā)作情況和血脂水平的變化。結(jié)果 治療后，治療組總有效率是95.00%，顯著高于對照組的77.50%（P<0.05）。治療后，兩組心絞痛持續(xù)時間、發(fā)作次數(shù)均顯著降低（P<0.05）；治療后，治療組心絞痛發(fā)作頻率和持續(xù)時間顯著低于對照組（P<0.05）。治療后，兩組低密度脂蛋白膽固醇（LDL-C）、總膽固醇（TC）、三酰甘油（TG）均較治療前顯著降低（P<0.05）；治療后治療組血脂水平低于對照組（P<0.05）。結(jié)論 美托洛爾聯(lián)合阿托伐他汀鈣治療冠心病心絞痛具有較好的臨床療效，可有效控制患者心絞痛發(fā)作頻率，改善其血脂水平，值得臨床推廣。

Objective To investigate the clinical effect of metoprolol combined with atorvastatin in treatment of coronary heart disease angina pectoris. Methods A total of 80 patients with coronary heart disease angina pectoris admitted to the People's Hospital of Gaozhou from January 2019 to December 2020 were selected as the study subjects. All patients were randomly divided into control group and treatment group, with 40 cases in each group. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. The drug doesag should be increased appropriately according to individual differences, and the total dosage should not be exceed 80 mg/d. Patients in the treatment group were po administered with Metoprolol Tartrate Sustained-release Tablets on the basis of the control group, 23.75 mg/time, once daily, with a maximum daily dosage not more than 100 mg. Both groups continued to take the drug for 6 months. The clinical efficacy of the two groups was observed and the changes of angina pectoris attack and blood lipid levels were compared between two groups. Results After treatment, the total effective rate of the treatment group was 95.00%, significantly higher than that of the control group (77.50%) (P<0.05). After treatment, the duration and frequency of angina pectoris in both groups were significantly decreased (P<0.05). After treatment, the frequency and duration of angina attack in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, the serum lipid level in the treatment group was lower than that in the control group (P<0.05). Conclusion Metoprolol combined with atorvastatin calcium has good clinical efficacy in the treatment of coronary heart disease angina pectoris, and can effectively control the frequency of angina pectoris attack and improve the level of blood lipid, which is worthy of clinical promotion.

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