目的 觀察明目蒺藜丸聯(lián)合聚乙烯醇滴眼液治療干眼癥的臨床療效。方法 選取2018年12月-2020年12月中國人民解放軍聯(lián)勤保障部隊第988醫(yī)院收治的180例干眼癥患者，根據(jù)信封抽簽法將患者分為對照組和治療組，各90例。對照組患者給予聚乙烯醇滴眼液，滴于患側(cè)眼部，1滴/次，3~4次/d。治療組在對照組治療的基礎(chǔ)上口服明目蒺藜丸，9 g/次，2次/d。兩組患者持續(xù)治療4周。觀察兩組療效，比較兩組的視覺相關(guān)生命質(zhì)量量表（NEI-VFQ-25）評分、干眼癥癥狀評分、淚液分泌試驗（SIT）、角膜熒光染色（FL）、淚膜破裂時間（BUT）、炎癥因子[腫瘤壞死因子-α（TNF-α）、超敏C反應(yīng)蛋白（hs-CRP）、白細胞介素-6（IL-6）]水平。結(jié)果 治療后，治療組的總有效率（94.44%）高于對照組（81.11%）（P<0.05）。治療后，兩組NEI-VFQ-25各維度評分升高（P<0.05），且治療組NEI-VFQ-25各維度評分高于對照組（P<0.05）。治療后，兩組干眼癥癥狀評分降低（P<0.05），且治療組干眼癥癥狀評分低于對照組（P<0.05）。治療后，兩組BUT、SIT升高，F(xiàn)L降低，差異有統(tǒng)計學(xué)意義（P<0.05）；治療組BUT、SIT高于對照組，F(xiàn)L低于對照組（P<0.05）。治療后，兩組TNF-α、IL-6、hs-CRP水平均顯著降低（P<0.05），治療組TNF-α、IL-6、hs-CRP水平低于對照組（P<0.05）。結(jié)論 明目蒺藜丸聯(lián)合聚乙烯醇滴眼液治療干眼癥的療效較好，能夠提高患者視覺相關(guān)生命質(zhì)量，改善癥狀，促進淚液分泌，增加淚膜穩(wěn)定性，減輕角結(jié)膜損傷，降低淚液中的炎癥因子水平。

Objective To observe the clinical effect of Mingmu Jili Pills combined with Polyvinyl Alcohol Eye Drops in treatment of dry eye. Methods Patients (180 cases) with dry eye in 988 Hospital of Joint Service Support Force of Chinese People's Liberation Army from December 2018 to December 2020 were divided into control and treatment groups according to the envelope lottery, and each group had 90 cases. Patients in the control group were given Polyvinyl Alcohol Eye Drops, 1 drop/time, 3-4 times daily. Patients in the treatment group were po administered with Mingmu Jili Pills on the basis of the control group, 9 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and NEI-VFQ-25 scores, dry eye symptom scores, SIT, FL, BUT, and inflammatory factor (TNF-α, hs-CRP, and IL-6) in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.44%) was higher than that of the control group (81.11%) (P<0.05). After treatment, the scores of NEI-VFQ-25 in two groups increased (P<0.05), and the scores of NEI-VFQ-25 in the treatment group were higher than those in the control group (P<0.05). After treatment, the symptom score of dry eye in two groups were decreased (P<0.05), and the symptom score of dry eye in the treatment group was lower than that in the control group (P<0.05). After treatment, the BUT and SIT in two groups were increased, but the FL in two groups were decreased (P<0.05). The BUT and SIT in the treatment group were higher than those in the control group, but the FL in the treatment group was lower than those in the control group (P<0.05). After treatment, the levels of TNF-α, IL-6, and hs-CRP in the two groups were significantly decreased (P<0.05), and the levels of TNF-α, IL-6, and hs-CRP in the treatment group were lower than those in the control group (P<0.05). Conclusion Mingmu Jili Pills combined with Polyvinyl Alcohol Eye Drops has clinical curative effect in treatment of dry eye, can improve patients' visual related quality of life, improve symptoms, promote tear secretion, increase tear film stability, reduce keratoconjunctival injury and reduce the level of inflammatory factors in tears.

R988.1

河南省醫(yī)學(xué)科技攻關(guān)計劃項目（2017T03237）