目的 研究3-{[（叔丁基二甲基硅基）氧基]甲基}環(huán)丁烷-1-羧酸的合成工藝路線。方法 以3-亞甲基環(huán)丁基腈為起始原料，經(jīng)過水解、還原、硅醚保護、硼氫化氧化、氧化等實驗操作合成3-{[（叔丁基二甲基硅基）氧基]甲基}環(huán)丁烷-1-羧酸。結(jié)果 合成了目標化合物，并利用NMR、HR-MS確證了結(jié)構(gòu)。結(jié)論 3-{[（叔丁基二甲基硅基）氧基]甲基}環(huán)丁烷-1-羧酸合成工藝操作性好，條件溫和，無需貴重試劑和柱色譜操作，適于工業(yè)化生產(chǎn)。

Objective To study the synthetic routes of 3-{[(tert-butyldimethylsilyl) oxy] methyl} cyclobutane-1-carboxylic acid. Methods With 3-methylenecyclobutane-1-carbonitrile as the starting material, 3-{[(tert-butyldimethylsilyl) oxy] methyl} cyclobutane-1-carboxylic acid was synthesized through optimized synthetic procedures by using tipical synthetic operations including:hydrolysis, reduction, protection, oxidation. Results The target molecule was successfully synthesized and the structure was confirmed by NMR and HR-MS spectroscopy. Conclusion The synthesis process of 3-{[(tert-butyldimethylsilyl) oxy] methyl} cyclobutane-1-carboxylic acid has good operability, mild conditions without using expensive transion metals and column-purification, which is quite suitable for industrial production.

R284.3