目的 探討脈絡(luò)通顆粒聯(lián)合非洛地平緩釋片治療冠心病變異型心絞痛的臨床療效。方法 選取2020年2月—2021年2月在阜外華中心血管病醫(yī)院進(jìn)行治療的88例冠心病變異型心絞痛患者為研究對象，根據(jù)住院先后順序分為對照組和治療組，每組各44例。對照組患者口服非洛地平緩釋片，5 mg/次，1次/d。治療組在對照組基礎(chǔ)上口服脈絡(luò)通顆粒，6 g/次，3次/d。兩組均治療4周進(jìn)行效果比較。觀察兩組的臨床療效，比較兩組治療前后心功能和血脂水平的變化情況。結(jié)果 經(jīng)治療，治療組心絞痛總有效率是97.73%，顯著高于對照組81.82%（P<0.05）。經(jīng)治療，治療組心電圖療效總有效率是97.73%，顯著高于對照組的84.09%（P<0.05）。經(jīng)治療，兩組心臟指數(shù)（CI）、E峰流速/A峰流速（E/A）、心排血量（CO）均較治療前顯著升高（P<0.05）；且治療后治療組心功能指標(biāo)優(yōu)于對照組（P<0.05）。經(jīng)治療，兩組血清三酰甘油（TG）、總膽固醇（TC）、低密度脂蛋白（LDL）水平均顯著下降，但高密度脂蛋白（HDL）水平均增高（P<0.05）；治療后，治療組血脂水平優(yōu)于對照組（P<0.05）。結(jié)論 脈絡(luò)通顆粒聯(lián)合非洛地平緩釋片治療冠心病變異型心絞痛具有較好的臨床療效，可有效改善患者癥狀，改善患者心功能、血脂水平，有著良好的臨床應(yīng)用價值。

Objective To investigate the effect of Mailuotong Granules combined with felodipine in treatment of coronary heart disease variant angina pectoris. Methods A total of 88 patients with coronary heart disease variant angina pectoris who were treated in Fuwai Huazhong Vascular Disease Hospital from February 2020 to February 2021 were selected as the research subjects. According to the order of hospitalization, they were divided into control group and treatment group, with 44 patients in each group. Patients in the control group were po administered with Felodipine Sustained Release Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Mailuotong Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, the changes of cardiac function and blood lipid levels were compared between the two groups before and after treatment. Results After treatment, the total effective rate of angina pectoris in the treatment group was 97.73%, which was significantly higher than that in the control group (81.82%, P < 0.05). After treatment, the total effective rate of ECG in the treatment group was 97.73%, which was significantly higher than that in the control group (84.09%, P < 0.05). After treatment, cardiac index (CI), peak velocity of E/A (E/A), and cardiac output (CO) in two groups were significantly increased compared with before treatment (P < 0.05). After treatment, the heart function of the treatment group was better than that of the control group (P < 0.05). After treatment, the serum triglyceride (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels in two groups were significantly decreased, but the high density lipoprotein (HDL) levels were increased (P < 0.05). After treatment, the level of blood lipid in the treatment group was better than that in the control group (P < 0.05). Conclusion Mailuotong Granules combined with felodipine has good clinical effect in treatment of coronary heart disease variant angina pectoris, and can effectively improve the symptoms of patients, improve the cardiac function and blood lipid levels, which has a good clinical value.

R972

河南省醫(yī)學(xué)科技攻關(guān)計劃項目（LHGJ20200096）