目的 分析監(jiān)利市人民醫(yī)院成人血流感染病原菌的分布及其耐藥性，為臨床合理使用抗菌藥物提供依據(jù)。方法 收集2016年1月—2020年12月監(jiān)利市人民醫(yī)院住院疑似血流感染的成年（年齡≥14歲）患者血培養(yǎng)陽性菌株，采用VITEK 2-Compact儀器法測定分離菌的藥物敏感性，參照CLSI 2020版折點(diǎn)判讀結(jié)果，用WHONET 5.6軟件統(tǒng)計(jì)分析。結(jié)果 共分離出1 431株病原菌，革蘭陰性桿菌占63.31%，革蘭陽性球菌占35.64%，真菌占1.05%；主要為大腸埃希菌（38.50%）、凝固酶陰性葡萄球菌（19.64%）、肺炎克雷伯菌（10.83%）、金黃色葡萄球菌（5.03%）和腸球菌屬（3.14%）。革蘭陰性桿菌對亞胺培南、美洛培南、哌拉西林/他唑巴坦、頭孢哌酮/舒巴坦較敏感。耐甲氧西林金黃色葡萄球菌（MRSA）和耐甲氧西林凝固酶陰性葡萄球菌（MRCNS）檢出率分別為16.7%、71.2%，未發(fā)現(xiàn)耐利奈唑胺、萬古霉素、替考拉寧和替加環(huán)素革蘭陽性球菌。結(jié)論 監(jiān)利市人民醫(yī)院成人血流感染病原菌以革蘭陰性菌為主，臨床應(yīng)合理應(yīng)用抗菌藥物，主動(dòng)開展細(xì)菌耐藥性監(jiān)測，并加強(qiáng)醫(yī)院感染控制遏制細(xì)菌耐藥性上升。

Objective To analyze the distribution and drug resistance of pathogenic bacteria from adult blood specimens, in order to further provide the reference for rational use of antibacterial agents. Methods The strains isolated from the blood in People’s Hospital of Jianli City from January 2016 to August 2020 were collected, the identification and antimicrobial susceptibility were performed by VITEK 2-Compact. Drug resistance was judged according to CLSI 2020 and WHONET 5. 6 software was used to analyze the data. Results A total of 1 431 bacterial strains were isolated. Gram-negative bacilli, Gram-positive cocci and fungus accounted for 63.31%, 35.64%, and 1.05%，respectively. They are mainly Escherichia coli, coagulase negative Staphylococcus, Klebsiella pneumonia, Staphylococcus aureus, and Enterococcus. Gram-negative bacilli are more sensitive to imipenem, meropenem, piperacillin/ tazobactam, and cefoperazone/sulbactam. The prevalence of methicillin resistant S. aureus (MRSA) and methicillin resistant coagulase negative Staphylococcus (MRCNS) were 16.7% and 71.2%, respectively. No Gram-positive cocci was resistant to linezolid, vancomycin, teicoplanin, and tigecycline. Conclusion Gram negative bacteria are the main pathogens of bloodstream infection in adult patients in People’s Hospital of Jianli City. Promoting the rational use of antimicrobial agents and conducting bacterial resistance surveillance actively should be strengthen to prevent the increase of the bacteria drug resistance.

R978.1